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    RTA1 Rta1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853127, updated on 17-May-2024

    Summary

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    Gene symbol
    RTA1
    Gene description
    Rta1p
    Primary source
    FungiDB:YGR213C
    Locus tag
    YGR213C
    See related
    SGD:S000003445; AllianceGenome:SGD:S000003445; VEuPathDB:YGR213C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RTA1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (918512..919465, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene zinc finger-containing protein ZPR1 Neighboring gene N-acetyltransferase Neighboring gene ribosomal 40S subunit protein S0A Neighboring gene mitochondrial 37S ribosomal protein RSM27

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The regulatory inputs controlling pleiotropic drug resistance and hypoxic response in yeast converge at the promoter of the aminocholesterol resistance gene RTA1. Kołaczkowska A, et al. FEMS Yeast Res, 2012 May. PMID 22129104
    2. Characterization of the Saccharomyces cerevisiae RTA1 gene involved in 7-aminocholesterol resistance. Soustre I, et al. Curr Genet, 1996 Jul 31. PMID 8660468
    3. Loop 5 region is important for the activity of the long-chain base transporter Rsb1. Makuta H, et al. J Biochem, 2017 Feb 1. PMID 28175317
    4. Role of PUG1 in inducible porphyrin and heme transport in Saccharomyces cerevisiae. Protchenko O, et al. Eukaryot Cell, 2008 May. PMID 18326586, Free PMC Article
    5. The nucleotide sequence of Saccharomyces cerevisiae chromosome VII. Tettelin H, et al. Nature, 1997 May 29. PMID 9169869

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RTA1 promoter responds to the status of the major repressors of hypoxic genes and activators of pleiotropic drug resistance.
      Title: The regulatory inputs controlling pleiotropic drug resistance and hypoxic response in yeast converge at the promoter of the aminocholesterol resistance gene RTA1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rta1p
    NP_011729.1
    • Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein; RTA1 has a paralog, YLR046C, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      918512..919465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181342.1 → NP_011729.1  TPA: Rta1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011729.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUZ6, E9P922, P53047
      UniProtKB/TrEMBL
      A0A8H8UKV1, A6ZUM4, N1P642
      Conserved Domains (1) summary
      pfam04479
      Location:72 → 275
      RTA1; RTA1 like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53047.1

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