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    DXO1 Dxo1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851976, updated on 29-Jun-2024

    Summary

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    Gene symbol
    DXO1
    Gene description
    Dxo1p
    Primary source
    FungiDB:YDR370C
    Locus tag
    YDR370C
    See related
    SGD:S000002778; AllianceGenome:SGD:S000002778; VEuPathDB:YDR370C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 5'-3' exonuclease activity. Involved in deadenylation-dependent decapping of nuclear-transcribed mRNA. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See DXO1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1217782..1219110, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene trifunctional aldehyde reductase/carbonyl reductase (NADPH)/glucose 1-dehydrogenase (NADP(+)) YPR1 Neighboring gene Xrs2p Neighboring gene putative chitinase Neighboring gene Vps74p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast Dxo1 is required for 25S rRNA maturation and acts as a transcriptome-wide distributive exonuclease. Hurtig JE, et al. RNA, 2022 May. PMID 35140172, Free PMC Article
    2. "NAD-capQ" detection and quantitation of NAD caps. Grudzien-Nogalska E, et al. RNA, 2018 Oct. PMID 30045887, Free PMC Article
    3. Dxo1 is a new type of eukaryotic enzyme with both decapping and 5'-3' exoribonuclease activity. Chang JH, et al. Nat Struct Mol Biol, 2012 Oct. PMID 22961381, Free PMC Article
    4. Extensive 5'-surveillance guards against non-canonical NAD-caps of nuclear mRNAs in yeast. Zhang Y, et al. Nat Commun, 2020 Nov 2. PMID 33139726, Free PMC Article
    5. No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5'-OH ends phosphorylated by Trl1. Navickas A, et al. Nat Commun, 2020 Jan 8. PMID 31913314, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 5'-3' RNA exonuclease activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables 5'-3' RNA exonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 5'-diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD-cap decapping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within NAD-cap decapping IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within NAD-cap decapping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of LSU-rRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, no-go decay IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Dxo1p
    NP_010658.3
    • Cytoplasmic 5' exoribonuclease; transcriptomics wide distributive exonuclease; involved in cytoplasmic mRNA degradation, turnover of tRNA introns and processing of spliceosomal introns; required for the final 5'-end processing of 25S rRNA; minor contributor to No-Go Decay and the unfolded protein response; decapping protein involved in surveillance and removal of non-canonical nicotinamide adenine dinucleotide (NAD) capped nuclear mRNAs (NAD-RNAs); sequence similarity to Rai1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1217782..1219110 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180678.3 → NP_010658.3  TPA: Dxo1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010658.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT01, Q06349
      UniProtKB/TrEMBL
      A0A8H8UNR6, A6ZYW8, B3LFT3, B5VGQ0, C8Z5T1, N1P8R2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06349.1

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