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    FRE1 ferric/cupric-chelate reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850911, updated on 7-Jul-2024

    Summary

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    Gene symbol
    FRE1
    Gene description
    ferric/cupric-chelate reductase
    Primary source
    FungiDB:YLR214W
    Locus tag
    YLR214W
    See related
    SGD:S000004204; AllianceGenome:SGD:S000004204; VEuPathDB:YLR214W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ferric-chelate reductase activity. Involved in copper ion import and iron ion transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See FRE1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (568567..570627)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene gamma-tubulin Neighboring gene putative glycosylase Neighboring gene cell proliferation protein CDC123 Neighboring gene peptidylprolyl isomerase CPR6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Copper homeostasis as a target to improve Saccharomyces cerevisiae tolerance to oxidative stress. Berterame NM, et al. Metab Eng, 2018 Mar. PMID 29477856
    2. Mutational reconstructed ferric chelate reductase confers enhanced tolerance in rice to iron deficiency in calcareous soil. Ishimaru Y, et al. Proc Natl Acad Sci U S A, 2007 May 1. PMID 17449639, Free PMC Article
    3. Inhibition of the yeast metal reductase heme protein fre1 by nitric oxide (NO): a model for inhibition of NADPH oxidase by NO. Shinyashiki M, et al. Free Radic Biol Med, 2004 Sep 1. PMID 15288128
    4. Candida albicans CFL1 encodes a functional ferric reductase activity that can rescue a Saccharomyces cerevisiae fre1 mutant. Hammacott JE, et al. Microbiology (Reading), 2000 Apr. PMID 10784045
    5. Regulation of high affinity iron uptake in the yeast Saccharomyces cerevisiae. Role of dioxygen and Fe. Hassett RF, et al. J Biol Chem, 1998 Mar 27. PMID 9516467

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data support the conclusion that FRE1 mRNA is immune to nonsense-mediated mRNA decay-mediated degradation under both inducing and non-inducing conditions.
      Title: Nonsense-mediated mRNA decay of the ferric and cupric reductase mRNAs FRE1 and FRE2 in Saccharomyces cerevisiae.
    2. Inhibition of Fre1 by nitric oxide also inhibited yeast growth in low-iron medium.
      Title: Inhibition of the yeast metal reductase heme protein fre1 by nitric oxide (NO): a model for inhibition of NADPH oxidase by NO.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ferric-chelate reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferric-chelate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferric-chelate reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ferric-chelate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in copper ion import IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in copper ion import IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in copper ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular iron ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transition metal ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ferric/cupric-chelate reductase
    NP_013315.1
    • Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      568567..570627
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182101.1 → NP_013315.1  TPA: ferric/cupric-chelate reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013315.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYL5, P32791
      UniProtKB/TrEMBL
      A0A8H4BY85, A7A1A2, C8ZDH8, G2WJ44, N1P1C4
      Conserved Domains (3) summary
      cd06186
      Location:414 → 684
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      pfam01794
      Location:261 → 374
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam05730
      Location:26 → 84
      CFEM; CFEM domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32791.1

    Gene LinkOut

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