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    SKS1 putative serine/threonine protein kinase SKS1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856081, updated on 29-Jun-2024

    Summary

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    Gene symbol
    SKS1
    Gene description
    putative serine/threonine protein kinase SKS1
    Primary source
    FungiDB:YPL026C
    Locus tag
    YPL026C
    See related
    SGD:S000005947; AllianceGenome:SGD:S000005947; VEuPathDB:YPL026C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SHA3
    Summary
    Enables protein kinase activity. Involved in several processes, including pseudohyphal growth; regulation of glucose transmembrane transport; and response to glucose. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SKS1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (500675..502183, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene acetyl-CoA C-acetyltransferase Neighboring gene Sma1p Neighboring gene Rmi1p Neighboring gene methylenetetrahydrofolate reductase (NAD(P)H) MET12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Nuclear Zip Code in SKS1 mRNA Promotes Its Slow Export, Nuclear Retention, and Degradation by the Nuclear Exosome/DRN in Saccharomyces cerevisiae. Das S, et al. J Mol Biol, 2019 Sep 6. PMID 31295459
    2. Identification of ubiquitin Ser57 kinases regulating the oxidative stress response in yeast. Hepowit NL, et al. Elife, 2020 Oct 19. PMID 33074099, Free PMC Article
    3. The SKS1 gene of Saccharomyces cerevisiae is required for long-term adaptation of snf3 null strains to low glucose. Vagnoli P, et al. Yeast, 1998 Mar 15. PMID 9559544
    4. A new laboratory evolution approach to select for constitutive acetic acid tolerance in Saccharomyces cerevisiae and identification of causal mutations. González-Ramos D, et al. Biotechnol Biofuels, 2016. PMID 27525042, Free PMC Article
    5. Analysis of the yeast kinome reveals a network of regulated protein localization during filamentous growth. Bharucha N, et al. Mol Biol Cell, 2008 Jul. PMID 18417610, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity HDA PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of glucose transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative serine/threonine protein kinase SKS1
    NP_015299.1
    • Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway; SKS1 has a paralog, VHS1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      500675..502183 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183840.1 → NP_015299.1  TPA: putative serine/threonine protein kinase SKS1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015299.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3Y7, Q12505
      UniProtKB/TrEMBL
      A0A8H4BV60, G2WPF3, N1NVZ5
      Conserved Domains (1) summary
      cl21453
      Location:9 → 331
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12505.1

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