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    PSY3 Psy3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851091, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PSY3
    Official Full Name
    Psy3p
    Primary source
    SGD:S000004368
    Locus tag
    YLR376C
    See related
    AllianceGenome:SGD:S000004368; FungiDB:YLR376C; VEuPathDB:YLR376C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in DNA recombinase assembly and error-free translesion synthesis. Located in nucleus and site of double-strand break. Part of Shu complex. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See PSY3 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (872826..873554, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Vid22p Neighboring gene Stp3p Neighboring gene fructose 1,6-bisphosphate 1-phosphatase Neighboring gene tRNA-Lys

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast FBP1 poly(A) signal functions in both orientations and overlaps with a gene promoter. Aranda A, et al. Nucleic Acids Res, 1998 Oct 15. PMID 9753725, Free PMC Article
    2. Genome-wide identification of genes conferring resistance to the anticancer agents cisplatin, oxaliplatin, and mitomycin C. Wu HI, et al. Cancer Res, 2004 Jun 1. PMID 15173006
    3. The YJL185C, YLR376C and YJR129C genes of Saccharomyces cerevisiae are probably involved in regulation of the glyoxylate cycle. Boniewska-Bernacka E, et al. Acta Biochim Pol, 2006. PMID 17146497
    4. Structural analysis of Shu proteins reveals a DNA binding role essential for resisting damage. Tao Y, et al. J Biol Chem, 2012 Jun 8. PMID 22465956, Free PMC Article
    5. Structural and SAXS analysis of the budding yeast SHU-complex proteins. She Z, et al. FEBS Lett, 2012 Jul 30. PMID 22749910

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study provides evidence that DNA-binding components of the budding yeast Shu complex, Csm2-Psy3, bind double-flap DNA substrates containing an abasic site analog, and increase chromatin association when abasic sites accumulate. Importantly, Csm2-Psy3 blocks AP endonuclease cleavage at a double-flap DNA substrate, thus preventing in vitro double-strand break formation.
      Title: The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway.
    2. Data indicate that Csm2, Psy3, Shu1 and Shu2 interact with each other in sequence to form a V-shape overall structure in Shu complex.
      Title: Structural basis for the functional role of the Shu complex in homologous recombination.
    3. The data suggest a model in which Csm2-Psy3 recruit the Shu complex to homologous recombination substrates, where it interacts with Rad51 through Rad55-Rad57 to stimulate Rad51 filament assembly and stability, promoting error-free repair.
      Title: The Shu complex interacts with Rad51 through the Rad51 paralogues Rad55-Rad57 to mediate error-free recombination.
    4. analysis of the crystal structure of the Psy3-Csm2 sub-complex
      Title: Structural and SAXS analysis of the budding yeast SHU-complex proteins.
    5. the contribution of the ER24 gene product Ylr376Cp and of the two suppressor gene products Yjl185Cp and Yjr129Cp to a complex regulation of the glyoxylate cycle in yeast.
      Title: The YJL185C, YLR376C and YJR129C genes of Saccharomyces cerevisiae are probably involved in regulation of the glyoxylate cycle.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombinase assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in error-free translesion synthesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in recombinational repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in recombinational repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in recombinational repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Shu complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Shu complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Shu complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in site of double-strand break IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Psy3p
    NP_013480.1
    • Component of Shu complex (aka PCSS complex); Shu complex also includes Shu1, Csm2, Shu2, and promotes error-free DNA repair; promotes Rad51p filament assembly; Shu complex mediates inhibition of Srs2p function; Psy3p and Csm2p contain similar DNA-binding regions which work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      872826..873554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182265.1 → NP_013480.1  TPA: Psy3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013480.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ12, Q12318
      UniProtKB/TrEMBL
      A7A1Q2, B3RHP2, C7GRW8, C8ZDY6, G2WJJ2, N1P7A0
      Conserved Domains (1) summary
      cd19480
      Location:2 → 226
      Psy3; Shu complex subunit Psy3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12318.1

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