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    SER2 phosphoserine phosphatase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853122, updated on 28-Oct-2024

    Summary

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    Official Symbol
    SER2
    Official Full Name
    phosphoserine phosphatase
    Primary source
    SGD:S000003440
    Locus tag
    YGR208W
    See related
    AllianceGenome:SGD:S000003440; FungiDB:YGR208W; VEuPathDB:YGR208W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables L-phosphoserine phosphatase activity. Involved in L-serine biosynthetic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in PSPH deficiency. Orthologous to human PSPH (phosphoserine phosphatase). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See SER2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (911883..912812)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ubiquitin-binding ESCRT-I subunit protein MVB12 Neighboring gene Cir1p Neighboring gene thioredoxin TRX2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. O-phosphoserine phosphatase from Baker's yeast. SCHRAMM M. J Biol Chem, 1958 Nov. PMID 13598753
    2. Genetic and physiological control of serine and glycine biosynthesis in Saccharomyces. Ulane R, et al. J Bacteriol, 1972 Jan. PMID 4333378, Free PMC Article
    3. Cloning and characterization of two novel chloroplastic glycerol-3-phosphate dehydrogenases from Dunaliella viridis. He Y, et al. Plant Mol Biol, 2009 Sep. PMID 19551475
    4. Genetic analysis of serine biosynthesis and glucose repression in yeast. Melcher K, et al. Curr Genet, 1992 Apr. PMID 1326413
    5. RNA Pol II Dynamics Modulate Co-transcriptional Chromatin Modification, CTD Phosphorylation, and Transcriptional Direction. Fong N, et al. Mol Cell, 2017 May 18. PMID 28506463, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables L-phosphoserine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-phosphoserine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-phosphoserine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-serine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-serine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-serine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    phosphoserine phosphatase
    NP_011724.1
    • Phosphoserine phosphatase of the phosphoglycerate pathway; involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      911883..912812
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181337.1 → NP_011724.1  TPA: phosphoserine phosphatase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011724.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUZ1, P42941
      UniProtKB/TrEMBL
      A6ZUL9, B3LI28, C7GRP1, C8Z9A1, G2WET7, N1P4A4
      Conserved Domains (1) summary
      TIGR00338
      Location:78 → 298
      serB; phosphoserine phosphatase SerB
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42941.1

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