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    SRP101 Signal recognition particle receptor subunit alpha [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851886, updated on 29-Jun-2024

    Summary

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    Gene symbol
    SRP101
    Gene description
    Signal recognition particle receptor subunit alpha
    Primary source
    FungiDB:YDR292C
    Locus tag
    YDR292C
    See related
    SGD:S000002700; AllianceGenome:SGD:S000002700; VEuPathDB:YDR292C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables signal recognition particle binding activity. Involved in protein targeting to ER. Located in endoplasmic reticulum membrane. Part of signal recognition particle receptor complex. Orthologous to human SRPRA (SRP receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SRP101 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1043146..1045011, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Rtt103p Neighboring gene ATP-dependent 3'-5' DNA helicase Neighboring gene mRNA-binding translational repressor SSD1 Neighboring gene sphinganine-1-phosphate aldolase DPL1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Signal recognition particle receptor is important for cell growth and protein secretion in Saccharomyces cerevisiae. Ogg SC, et al. Mol Biol Cell, 1992 Aug. PMID 1327299, Free PMC Article
    2. Does a deficiency of the signal recognition particle (SRP)-pathway affect the biosynthesis of its components in Saccharomyces cerevisiae and Escherichia coli? Kovalskaya ON, et al. Biochemistry (Mosc), 2006 Jul. PMID 16903826
    3. Structural basis for the function of the beta subunit of the eukaryotic signal recognition particle receptor. Schwartz T, et al. Cell, 2003 Mar 21. PMID 12654246
    4. A functional GTPase domain, but not its transmembrane domain, is required for function of the SRP receptor beta-subunit. Ogg SC, et al. J Cell Biol, 1998 Jul 27. PMID 9679135, Free PMC Article
    5. The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane. Miller JD, et al. J Cell Biol, 1995 Feb. PMID 7844142, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signal recognition particle binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signal recognition particle binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to ER IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal recognition particle receptor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Signal recognition particle receptor subunit alpha
    NP_010578.3
    • Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1043146..1045011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180600.3 → NP_010578.3  TPA: Signal recognition particle receptor subunit alpha [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010578.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSS1, P32916, Q05553
      UniProtKB/TrEMBL
      A0A8H8UNJ3, B3LG03, G2WB30, N1P728
      Conserved Domains (3) summary
      cd17876
      Location:398 → 619
      SRalpha_C; C-terminal domain of signal recognition particle receptor alpha subunit
      pfam09201
      Location:1 → 155
      SRX; signal recognition particle receptor alpha subunit
      pfam02881
      Location:300 → 370
      SRP54_N; SRP54-type protein, helical bundle domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32916.2

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