CIA2 iron-sulfur cluster assembly protein CIA2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CIA2
Official Full Name: iron-sulfur cluster assembly protein CIA2
Primary source: SGD:S000001164
Locus tag: YHR122W
See related: AllianceGenome:SGD:S000001164; FungiDB:YHR122W; VEuPathDB:YHR122W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Involved in iron-sulfur cluster assembly. Located in cytoplasm and nucleus. Part of CIA complex. Orthologous to human CIAO2B (cytosolic iron-sulfur assembly component 2B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CIA2 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (353625..354320)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

E208A-iron-sulfur cluster assembly protein CIA2 (Cia2) results in a diminished activity of the cytosolic iron sulfur cluster protein.
Title: Defining the domains of Cia2 required for its essential function in vivo and in vitro.
results suggest the involvement of Cia2p in oxidative and endoplasmic reticulum stress responses in yeast
Title: CIA2 deficiency results in impaired oxidative stress response and enhanced intracellular basal UPR activity in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in iron-sulfur cluster assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein maturation by [4Fe-4S] cluster transfer	IEA Inferred from Electronic Annotation more info
involved_in protein maturation by iron-sulfur cluster transfer	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
part_of cytosolic [4Fe-4S] assembly targeting complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: iron-sulfur cluster assembly protein CIA2

NP_011990.1

Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation and maturation of a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

353625..354320

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179252.1 → NP_011990.1 TPA: iron-sulfur cluster assembly protein CIA2 [Saccharomyces cerevisiae S288C]

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DL72, P38829

UniProtKB/TrEMBL

A6ZT30, B3LSN7, B5VK57, C7GR68, C8Z9R5, N1P156

Conserved Domains (1) summary

COG5133
Location:1 → 231

COG5133; Uncharacterized conserved protein [Function unknown]