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    sup35 eRF3-like class 2 translation release factor sup35 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539479, updated on 18-Sep-2024

    Summary

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    Official Symbol
    sup35
    Official Full Name
    eRF3-like class 2 translation release factor sup35
    Primary source
    PomBase:SPCC584.04
    Locus tag
    SPOM_SPCC584.04
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    erf3; sup9
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    Genomic context

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    See sup35 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003421.2 (1535399..1538011)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene GTPase regulator Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SNARE-binding protein Sec1 Neighboring gene single-stranded DNA-binding protein Ssb2 Neighboring gene ncRNA Neighboring gene G-protein-coupled receptor Git3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure and functional analysis of the eukaryotic class II release factor eRF3 from S. pombe. Kong C, et al. Mol Cell, 2004 Apr 23. PMID 15099522
    2. The stretch of C-terminal acidic amino acids of translational release factor eRF1 is a primary binding site for eRF3 of fission yeast. Ito K, et al. RNA, 1998 Aug. PMID 9701287, Free PMC Article
    3. Nonsense codon suppression in fission yeast due to mutations of tRNA(Ser.11) and translation release factor Sup35 (eRF3). Protacio RU, et al. Curr Genet, 2015 May. PMID 25519804, Free PMC Article
    4. The Schizosaccharomyces pombe Hsp104 disaggregase is unable to propagate the [PSI] prion. Sénéchal P, et al. PLoS One, 2009 Sep 11. PMID 19759825, Free PMC Article
    5. Structure of the Dom34-Hbs1 complex and implications for no-go decay. Chen L, et al. Nat Struct Mol Biol, 2010 Oct. PMID 20890290

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we localized another suppressor gene to the sup35 locus and we determined that the mechanism of suppression involves an amino acid substitution in a GTP elongation factor Tu domain of the ubiquitous eukaryotic translation release factor 3 (eRF3).
      Title: Nonsense codon suppression in fission yeast due to mutations of tRNA(Ser.11) and translation release factor Sup35 (eRF3).
    2. Hsp104 disaggregase is unable to propagate the [PSI] prion
      Title: The Schizosaccharomyces pombe Hsp104 disaggregase is unable to propagate the [PSI] prion.
    3. eRF1's M domain contacts eRF3's GTPase domain
      Title: Structural insights into eRF3 and stop codon recognition by eRF1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to translation release factor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    contributes_to translation release factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translational termination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    part_of translation release factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of translation release factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of translation release factor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eRF3-like class 2 translation release factor sup35

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1535399..1538011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023215.3 → NP_588225.1  eRF3-like class 2 translation release factor sup35 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588225.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74718, P78857
      Conserved Domains (4) summary
      cd01883
      Location:240 → 462
      EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
      COG5256
      Location:236 → 662
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
      cd03698
      Location:468 → 549
      eRF3_II_like; Domain II of the eukaryotic class II release factor-like proteins
      cd03704
      Location:555 → 660
      eRF3_C_III; C-terminal domain of eRF3
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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