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    DAL5 allantoate permease [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853617, updated on 2-Nov-2024

    Summary

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    Official Symbol
    DAL5
    Official Full Name
    allantoate permease
    Primary source
    SGD:S000003913
    Locus tag
    YJR152W
    See related
    AllianceGenome:SGD:S000003913; FungiDB:YJR152W; VEuPathDB:YJR152W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    UREP1
    Summary
    Enables allantoate transmembrane transporter activity and dipeptide transmembrane transporter activity. Involved in allantoate transport; dipeptide transport; and tripeptide transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25; gout; porokeratosis; and sialuria. Orthologous to several human genes including SLC17A1 (solute carrier family 17 member 1); SLC17A2 (solute carrier family 17 member 2); and SLC17A3 (solute carrier family 17 member 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See DAL5 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (719666..721297)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Dan4p Neighboring gene uncharacterized protein Neighboring gene endo-polygalacturonase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ureidosuccinic acid permeation in Saccharomyces cerevisiae. Greth ML, et al. Biochim Biophys Acta, 1977 Feb 14. PMID 13831
    2. Ureidosuccinate is transported by the allantoate transport system in Saccharomyces cerevisiae. Turoscy V, et al. J Bacteriol, 1987 Jun. PMID 3294799, Free PMC Article
    3. Transcriptional regulation of the DAL5 gene in Saccharomyces cerevisiae. Rai R, et al. J Bacteriol, 1987 Aug. PMID 3301804, Free PMC Article
    4. Ureidosuccinic acid uptake in yeast and some aspects of its regulation. Drillien R, et al. J Bacteriol, 1972 Jan. PMID 4550662, Free PMC Article
    5. Structure and transcription of the allantoate permease gene (DAL5) from Saccharomyces cerevisiae. Rai R, et al. J Bacteriol, 1988 Jan. PMID 3275614, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pph21-Myc(13) (Ppp21 tagged at the C terminus with 13 copies of the Myc epitope) weakly associates with the DAL5 promoter in a Gat1-dependent manner, whereas a similar Pph22-Myc(13) association requires both Gln3 and Gat1.
      Title: Intranuclear function for protein phosphatase 2A: Pph21 and Pph22 are required for rapamycin-induced GATA factor binding to the DAL5 promoter in yeast.
    2. Tor pathway control of the nitrogen-responsive DAL5 gene bifurcates at the level of Gln3 and Gat1 regulation in Saccharomyces cerevisiae
      Title: Tor pathway control of the nitrogen-responsive DAL5 gene bifurcates at the level of Gln3 and Gat1 regulation in Saccharomyces cerevisiae.
    3. These studies highlight the complementary activities of two dipeptide transport systems under different regulatory controls in common laboratory yeast strains.
      Title: Differential regulation and substrate preferences in two peptide transporters of Saccharomyces cerevisiae.
    4. IT is shown that clearly one (UAS(B)), and possibly two (UAS(A)), additional cis-acting elements are required for full DAL5 expression
      Title: Synergistic operation of four cis-acting elements mediate high level DAL5 transcription in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables allantoate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables allantoate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables dipeptide transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dipeptide transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables dipeptide transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in allantoate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in allantoate transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dipeptide transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dipeptide transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dipeptide transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dipeptide transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tripeptide transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tripeptide transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    allantoate permease
    NP_012686.3
    • Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      719666..721297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181810.3 → NP_012686.3  TPA: allantoate permease [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012686.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWX1, P15365
      UniProtKB/TrEMBL
      B3LQN2, C8ZBV2, G2WHF9, N1P3R9
      Conserved Domains (1) summary
      cd17327
      Location:80 → 496
      MFS_FEN2_like; Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15365.1

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