UTP25 rRNA-binding ribosome biosynthesis protein UTP25 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: UTP25
Gene description: rRNA-binding ribosome biosynthesis protein UTP25
Primary source: FungiDB:YIL091C
Locus tag: YIL091C
See related: SGD:S000001353; AllianceGenome:SGD:S000001353
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables U3 snoRNA binding activity and rRNA binding activity. Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of small-subunit processome. Orthologous to human UTP25 (UTP25 small subunit processor component). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See UTP25 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (191030..193195, complement)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that Nop19p (renamed from YGR251W) interacts preferentially with the DEAH-box RNA helicase Dhr2p and Utp25p.
Title: The nucleolar protein Nop19p interacts preferentially with Utp25p and Dhr2p and is essential for the production of the 40S ribosomal subunit in Saccharomyces cerevisiae.
YIL091C/UTP25 is a novel SSU processome component that, along with Utp3, forms the first identified interactions among the different SSU processome subcomplexes
Title: The DEAD-box RNA helicase-like Utp25 is an SSU processome component.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables U3 snoRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables U3 snoRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables U3 snoRNA binding	IEA Inferred from Electronic Annotation more info
enables rRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in ribosomal small subunit biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleolus	HDA more info	PubMed
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	IDA Inferred from Direct Assay more info	PubMed
part_of small-subunit processome	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: rRNA-binding ribosome biosynthesis protein UTP25

NP_012175.1

Nucleolar protein; required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

191030..193195 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179439.1 → NP_012175.1 TPA: rRNA-binding ribosome biosynthesis protein UTP25 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012175.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVJ6, P40498

UniProtKB/TrEMBL

A0A6V8RUI2, G2WG61, N1P0X9

Conserved Domains (1) summary

pfam06862
Location:248 → 720

UTP25; Utp25, U3 small nucleolar RNA-associated SSU processome protein 25