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    GNA1 glucosamine 6-phosphate N-acetyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850529, updated on 17-May-2024

    Summary

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    Gene symbol
    GNA1
    Gene description
    glucosamine 6-phosphate N-acetyltransferase
    Primary source
    FungiDB:YFL017C
    Locus tag
    YFL017C
    See related
    SGD:S000001877; AllianceGenome:SGD:S000001877; VEuPathDB:YFL017C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PAT1
    Summary
    Enables glucosamine 6-phosphate N-acetyltransferase activity. Involved in UDP-N-acetylglucosamine biosynthetic process. Located in cytoplasm and nucleus. Used to study cancer and keratosis follicularis spinulosa decalvans. Orthologous to human GNPNAT1 (glucosamine-phosphate N-acetyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GNA1 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (103983..104462, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene dihydrolipoyl dehydrogenase Neighboring gene mRNA splicing protein SMX2 Neighboring gene Mdj1p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modular pathway engineering of Bacillus subtilis for improved N-acetylglucosamine production. Liu Y, et al. Metab Eng, 2014 May. PMID 24560814
    2. The crystal structures of Apo and complexed Saccharomyces cerevisiae GNA1 shed light on the catalytic mechanism of an amino-sugar N-acetyltransferase. Peneff C, et al. J Biol Chem, 2001 May 11. PMID 11278591
    3. PAT1, an evolutionarily conserved acetyltransferase homologue, is required for multiple steps in the cell cycle. Lin R, et al. Genes Cells, 1996 Oct. PMID 9077451
    4. Saccharomyces cerevisiae GNA1, an essential gene encoding a novel acetyltransferase involved in UDP-N-acetylglucosamine synthesis. Mio T, et al. J Biol Chem, 1999 Jan 1. PMID 9867860
    5. The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae. Alme EB, et al. PLoS Genet, 2020 Jun. PMID 32579556, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucosamine 6-phosphate N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucosamine 6-phosphate N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucosamine 6-phosphate N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-N-acetylglucosamine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UDP-N-acetylglucosamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UDP-N-acetylglucosamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    glucosamine 6-phosphate N-acetyltransferase
    NP_116637.1
    • Glucosamine-6-phosphate acetyltransferase; evolutionarily conserved; required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      103983..104462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179949.1 → NP_116637.1  TPA: glucosamine 6-phosphate N-acetyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116637.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTL3, P43577
      UniProtKB/TrEMBL
      A0A6A5PWK9, A7A222, G2WDC4, N1P4L7
      Conserved Domains (1) summary
      cl17182
      Location:5 → 155
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43577.1

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