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    DOP1 Dop1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851719, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DOP1
    Official Full Name
    Dop1p
    Primary source
    SGD:S000002548
    Locus tag
    YDR141C
    See related
    AllianceGenome:SGD:S000002548; FungiDB:YDR141C; VEuPathDB:YDR141C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in cell morphogenesis; retrograde transport, endosome to Golgi; and retrograde transport, vesicle recycling within Golgi. Located in endosome and trans-Golgi network. Orthologous to several human genes including DOP1B (DOP1 leucine zipper like protein B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See DOP1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (734901..739997, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene NEDD8 family protein RUB1 Neighboring gene S-adenosylmethionine-dependent methyltransferase Neighboring gene Pex7p Neighboring gene ubiquitin-protein ligase SAN1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast Dop1 is required for glycosyltransferase retrieval from the trans-Golgi network. Zhao SB, et al. Biochim Biophys Acta Gen Subj, 2019 Jun. PMID 30981741
    2. C21orf5, a new member of Dopey family involved in morphogenesis, could participate in neurological alterations and mental retardation in Down syndrome. Rachidi M, et al. DNA Res, 2005. PMID 16303751
    3. Mon2 is a negative regulator of the monomeric G protein, Arl1. Manlandro CM, et al. FEMS Yeast Res, 2012 Sep. PMID 22594927
    4. Oligomeric Dop1p is part of the endosomal Neo1p-Ysl2p-Arl1p membrane remodeling complex. Barbosa S, et al. Traffic, 2010 Aug. PMID 20477991
    5. Yeast Mon2p is a highly conserved protein that functions in the cytoplasm-to-vacuole transport pathway and is required for Golgi homeostasis. Efe JA, et al. J Cell Sci, 2005 Oct 15. PMID 16219684

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results indicate that Dop1 is involved in vesicular transport at the TGN, and is critical for retrieving glycosyltransferases from the TGN to the Golgi in yeast.
      Title: Yeast Dop1 is required for glycosyltransferase retrieval from the trans-Golgi network.
    2. Data show that Dop1p localizes to endosomes and exists in a complex with Neo1p-Ysl2p-Arl1p.
      Title: Oligomeric Dop1p is part of the endosomal Neo1p-Ysl2p-Arl1p membrane remodeling complex.
    3. Dop1 plays a widespread role in membrane organization, and Mon2 acts as a scaffold to recruit the Golgi-localized pool of Dop1
      Title: Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde transport, vesicle recycling within Golgi IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in cytosol HDA PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Dop1p
    NP_010425.1
    • Protein involved in vesicular transport at trans-Golgi network (TGN); TGN-localized, leucine-zipper domain protein; involved in endosome-to-Golgi transport during endocytic recycling, and retrograde transport of glycosyltransferases from the TGN to the Golgi; involved in organization of the ER, establishment of cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      734901..739997 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180448.1 → NP_010425.1  TPA: Dop1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010425.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSC4, Q03921
      UniProtKB/TrEMBL
      C7GIP6, G2WAP1, N1P897
      Conserved Domains (1) summary
      COG5221
      Location:6 → 1698
      DOP1; Dopey and related predicted leucine zipper transcription factors [Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03921.1

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