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    ROQ1 Roq1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853297, updated on 29-Jun-2024

    Summary

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    Gene symbol
    ROQ1
    Gene description
    Roq1p
    Primary source
    FungiDB:YJL144W
    Locus tag
    YJL144W
    See related
    SGD:S000003680; AllianceGenome:SGD:S000003680; VEuPathDB:YJL144W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ubiquitin-protein transferase regulator activity. Involved in cellular response to water deprivation and stress-induced homeostatically regulated protein degradation pathway. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ROQ1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (146359..146673)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Ids2p Neighboring gene Sfh5p Neighboring gene protein transporter TIM17 Neighboring gene Irc9p Neighboring gene serine/threonine protein kinase YAK1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of two hydrophilins that contribute to the desiccation and freezing tolerance of yeast (Saccharomyces cerevisiae) cells. Dang NX, et al. Cryobiology, 2011 Jun. PMID 21420397
    2. Global analysis of nutrient control of gene expression in Saccharomyces cerevisiae during growth and starvation. Wu J, et al. Proc Natl Acad Sci U S A, 2004 Mar 2. PMID 14973188, Free PMC Article
    3. Genomic expression programs in the response of yeast cells to environmental changes. Gasch AP, et al. Mol Biol Cell, 2000 Dec. PMID 11102521, Free PMC Article
    4. The STF2p hydrophilin from Saccharomyces cerevisiae is required for dehydration stress tolerance. López-Martínez G, et al. PLoS One, 2012. PMID 22442684, Free PMC Article
    5. SHRED Is a Regulatory Cascade that Reprograms Ubr1 Substrate Specificity for Enhanced Protein Quality Control during Stress. Szoradi T, et al. Mol Cell, 2018 Jun 21. PMID 29861160

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ubiquitin-protein transferase regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ubiquitin-protein transferase regulator activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to stress IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in cellular response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to water deprivation ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in stress-induced homeostatically regulated protein degradation pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    Roq1p
    NP_012391.1
    • Ub-ligase substrate-specificity factor; proteolytically-cleaved form acts as a pseudosubstrate, binding and altering the substrate specificity of Ubr1p towards misfolded and native ER membrane and cytosolic proteins, as part of the stress-induced homeostatically regulated protein degradation (SHRED) pathway; hydrophilin essential during desiccation-rehydration; induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      146359..146673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181577.1 → NP_012391.1  TPA: Roq1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012391.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW41, P47009
      UniProtKB/TrEMBL
      A0A8H4BYD0, A6ZQI6, B3LPX5, C7GPY7, C8ZB75, N1P1H1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47009.1

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