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    KRE5 Kre5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854514, updated on 18-Sep-2024

    Summary

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    Official Symbol
    KRE5
    Official Full Name
    Kre5p
    Primary source
    SGD:S000005863
    Locus tag
    YOR336W
    See related
    AllianceGenome:SGD:S000005863; FungiDB:YOR336W; VEuPathDB:YOR336W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables UDP-glucose:glycoprotein glucosyltransferase activity. Involved in fungal-type cell wall beta-glucan biosynthetic process. Located in endoplasmic reticulum. Orthologous to human UGGT1 (UDP-glucose glycoprotein glucosyltransferase 1) and UGGT2 (UDP-glucose glycoprotein glucosyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See KRE5 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (949773..953870)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Mrs2p Neighboring gene alanine--tRNA ligase Neighboring gene Tea1p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. KRE5 gene null mutant strains of Candida albicans are avirulent and have altered cell wall composition and hypha formation properties. Herrero AB, et al. Eukaryot Cell, 2004 Dec. PMID 15590817, Free PMC Article
    2. The yeast KRE5 gene encodes a probable endoplasmic reticulum protein required for (1----6)-beta-D-glucan synthesis and normal cell growth. Meaden P, et al. Mol Cell Biol, 1990 Jun. PMID 2188106, Free PMC Article
    3. Loss of function of KRE5 suppresses temperature sensitivity of mutants lacking mitochondrial anionic lipids. Zhong Q, et al. Mol Biol Cell, 2005 Feb. PMID 15563612, Free PMC Article
    4. Functional, comparative and cell biological analysis of Saccharomyces cerevisiae Kre5p. Levinson JN, et al. Yeast, 2002 Oct. PMID 12271460
    5. Saccharomyces cerevisiae Big1p, a putative endoplasmic reticulum membrane protein required for normal levels of cell wall beta-1,6-glucan. Azuma M, et al. Yeast, 2002 Jun 30. PMID 12112232

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables UDP-glucose:glycoprotein glucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-glucose:glycoprotein glucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-glucose:glycoprotein glucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP-glucosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fungal-type cell wall beta-glucan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Kre5p
    NP_014981.1
    • Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      949773..953870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183756.1 → NP_014981.1  TPA: Kre5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014981.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W331, P22023, Q12190
      UniProtKB/TrEMBL
      A6ZPG6, B3LJZ5, N1P3U6
      Conserved Domains (3) summary
      pfam18401
      Location:254 → 372
      Thioredoxin_13; Thioredoxin-like domain
      pfam18402
      Location:419 → 576
      Thioredoxin_14; Thioredoxin-like domain
      pfam18404
      Location:1095 → 1306
      Glyco_transf_24; Glucosyltransferase 24
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22023.2

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