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    cnp3 centromere protein [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539620, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cnp3
    Official Full Name
    centromere protein
    Primary source
    PomBase:SPBC1861.01c
    Locus tag
    SPOM_SPBC1861.01C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    mif2; SPBC56F2.13
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    Genomic context

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    See cnp3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003423.3 (4126318..4128666, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene F-box protein Pof12 Neighboring gene mitochondrial 54S ribosomal protein mL53 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparison of Dam tagging and chromatin immunoprecipitation as tools for the identification of the binding sites for S. pombe CENP-C. Holland S, et al. Chromosome Res, 2005. PMID 15791413
    2. Fission Yeast CENP-C (Cnp3) Plays a Role in Restricting the Site of CENP-A Accumulation. Suma M, et al. G3 (Bethesda), 2018 Jul 31. PMID 29925533, Free PMC Article
    3. Structures of CENP-C cupin domains at regional centromeres reveal unique patterns of dimerization and recruitment functions for the inner pocket. Chik JK, et al. J Biol Chem, 2019 Sep 20. PMID 31366733, Free PMC Article
    4. The kinetochore protein Moa1 enables cohesion-mediated monopolar attachment at meiosis I. Yokobayashi S, et al. Cell, 2005 Dec 2. PMID 16325576
    5. Phosphorylation of CENP-C by Aurora B facilitates kinetochore attachment error correction in mitosis. Zhou X, et al. Proc Natl Acad Sci U S A, 2017 Dec 12. PMID 29180432, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cnp3-1 mutant is prone to promiscuous accumulation of Cnp1 at non-centromeric regions. Cnp3 plays a role in restricting the site of accumulation of Cnp1 and thus prevents formation of de novo centromeres.
      Title: Fission Yeast CENP-C (Cnp3) Plays a Role in Restricting the Site of CENP-A Accumulation.
    2. Residues 26-50 in Cnp3 are responsible for interacting with the Mis12 complex. Cnp3 is a substrate of Ark1 and phosphorylation impairs the interaction between the Cnp3 and Mis12 complex.
      Title: Phosphorylation of CENP-C by Aurora B facilitates kinetochore attachment error correction in mitosis.
    3. CENP-C serves as a scaffold for the specific recruitment of essential kinetochore proteins
      Title: CENP-C functions as a scaffold for effectors with essential kinetochore functions in mitosis and meiosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables centromeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables centromeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinetochore adaptor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables kinetochore adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in attachment of mitotic spindle microtubules to kinetochore IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in attachment of mitotic spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in kinetochore assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle attachment to meiosis I kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle attachment to meiosis I kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    centromere protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      4126318..4128666 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001355836.2 → NP_001342907.1  centromere protein [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9USR9, Q9USY5
      Conserved Domains (2) summary
      pfam15624
      Location:18 → 69
      Mif2_N; Kinetochore CENP-C fungal homolog, Mif2, N-terminal
      cl21464
      Location:539 → 624
      cupin_like; Conserved domain found in cupin and related proteins
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials