OXR1 Oxr1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: OXR1
Gene description: Oxr1p
Primary source: FungiDB:YPL196W
Locus tag: YPL196W
See related: SGD:S000006117; AllianceGenome:SGD:S000006117; VEuPathDB:YPL196W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Involved in cellular response to oxidative stress. Located in mitochondrion. Human ortholog(s) of this gene implicated in cerebellar hyplasia/atrophy, epilepsy, and global developmental delay. Orthologous to several human genes including TLDC2 (TBC/LysM-associated domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Molecular mechanism of Oxr1p mediated disassembly of yeast V-ATPase.
Title: Molecular mechanism of Oxr1p mediated disassembly of yeast V-ATPase.
Oxidative stress protein Oxr1 promotes V-ATPase holoenzyme disassembly in catalytic activity-independent manner.
Title: Oxidative stress protein Oxr1 promotes V-ATPase holoenzyme disassembly in catalytic activity-independent manner.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein retention in Golgi apparatus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein-containing complex disassembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein-containing complex disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of proton-transporting ATPase activity, rotational mechanism	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of proton-transporting ATPase activity, rotational mechanism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

NP_015128.1

Protein that regulates the vacuolar V-ATPase; inhibits V1-ATPase activity and triggers ATP-dependent disassembly of the V-ATPase holoenzyme, counteracting the function of the RAVE complex; localizes to the cytoplasm; required for retention of the vacuolar-ATPase V0 domain subunit Stv1p in pre-vacuolar compartments; involved in resistance to oxidative damage; member of a conserved family of TLDc domain proteins found in eukaryotes; contains an N-terminal EF-hand-like domain

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain