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    skp1 SCF ubiquitin ligase complex subunit Skp1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540917, updated on 22-Jun-2024

    Summary

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    Gene symbol
    skp1
    Gene description
    SCF ubiquitin ligase complex subunit Skp1
    Locus tag
    SPOM_SPBC409.05
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    psh1; sph1
    Old locus tag
    SPBC409.05
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    Genomic context

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    See skp1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003423.3 (1140128..1141240)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene MIS12/MIND complex Mis12 Neighboring gene ncRNA Neighboring gene protein Swi5 Neighboring gene ncRNA Neighboring gene ubiquitin hydrolase Uch2 Neighboring gene ncRNA Neighboring gene MAP kinase kinase Wis1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fission yeast Skp1 is required for spindle morphology and nuclear membrane segregation at anaphase. Lehmann A, et al. FEBS Lett, 2004 May 21. PMID 15147872
    2. Essential and distinct roles of the F-box and helicase domains of Fbh1 in DNA damage repair. Sakaguchi C, et al. BMC Mol Biol, 2008 Mar 3. PMID 18312697, Free PMC Article
    3. Skp1 and the F-box protein Pof6 are essential for cell separation in fission yeast. Hermand D, et al. J Biol Chem, 2003 Mar 14. PMID 12511573
    4. Identification of a conserved F-box protein 6 interactor essential for endocytosis and cytokinesis in fission yeast. Jourdain I, et al. Biochem J, 2009 May 13. PMID 19243310, Free PMC Article
    5. Fission yeast Mcl1 interacts with SCF(Pof3) and is required for centromere formation. Mamnun YM, et al. Biochem Biophys Res Commun, 2006 Nov 10. PMID 16997270

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic nuclear membrane biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear envelope organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in resolution of meiotic recombination intermediates IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RAVE complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    part_of nuclear SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of single-stranded DNA-dependent ATP-dependent DNA helicase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SCF ubiquitin ligase complex subunit Skp1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1140128..1141240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021365.3 → NP_595455.1  SCF ubiquitin ligase complex subunit Skp1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595455.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9Y709
      Conserved Domains (3) summary
      smart00512
      Location:1 → 110
      Skp1; Found in Skp1 protein family
      COG5201
      Location:1 → 161
      SKP1; SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones]
      pfam01466
      Location:84 → 158
      Skp1; Skp1 family, dimerization domain
    Nucleotide Protein
    Heading Accession and Version

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