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    OGG1 8-oxoguanine glycosylase OGG1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854942, updated on 29-Jun-2024

    Summary

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    Gene symbol
    OGG1
    Gene description
    8-oxoguanine glycosylase OGG1
    Primary source
    FungiDB:YML060W
    Locus tag
    YML060W
    See related
    SGD:S000004525; AllianceGenome:SGD:S000004525; VEuPathDB:YML060W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables oxidized purine nucleobase lesion DNA N-glycosylase activity. Involved in base-excision repair, AP site formation; error-free translesion synthesis; and telomere maintenance via telomerase. Located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; angiomyolipoma; carcinoma (multiple); eye disease (multiple); and reproductive organ cancer (multiple). Orthologous to human OGG1 (8-oxoguanine DNA glycosylase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See OGG1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (151871..153001)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Mft1p Neighboring gene DNA helicase PIF1 Neighboring gene lysophospholipase Neighboring gene Hug1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of 8-oxoguanine DNA glycosylase of Trypanosoma cruzi. Furtado C, et al. PLoS One, 2012. PMID 22876325, Free PMC Article
    2. Saccharomyces cerevisiae Ogg1 prevents poly(GT) tract instability in the mitochondrial genome. Vongsamphanh R, et al. DNA Repair (Amst), 2006 Feb 3. PMID 16293446
    3. Excision of 8-oxoguanine within clustered damage by the yeast OGG1 protein. David-Cordonnier MH, et al. Nucleic Acids Res, 2001 Mar 1. PMID 11222760, Free PMC Article
    4. Identification of proteins of Escherichia coli and Saccharomyces cerevisiae that specifically bind to C/C mismatches in DNA. Nakahara T, et al. Nucleic Acids Res, 2000 Jul 1. PMID 10871405, Free PMC Article
    5. Catalytic and DNA binding properties of the ogg1 protein of Saccharomyces cerevisiae: comparison between the wild type and the K241R and K241Q active-site mutant proteins. Guibourt N, et al. Biochemistry, 2000 Feb 22. PMID 10677220

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In Saccharomyces cerevisiae ablation of Ogg1p leads to an increase in oxidized guanine level in telomeric DNA.
      Title: Deletion of Ogg1 DNA glycosylase results in telomere base damage and length alteration in yeast.
    2. Ogg1 prevents poly(GT) tract instability in the mitochondrial genome
      Title: Saccharomyces cerevisiae Ogg1 prevents poly(GT) tract instability in the mitochondrial genome.
    3. The roles of OGG1 and NTG2 genes in the repair of lethal and mutagenic oxidative lesions induced by H2O2 and their relationships with iron and copper ions are discussed.
      Title: Role of OGG1 and NTG2 in the repair of oxidative DNA damage and mutagenesis induced by hydrogen peroxide in Saccharomyces cerevisiae: relationships with transition metals iron and copper.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidized base lesion DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidized purine nucleobase lesion DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in base-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in base-excision repair, AP site formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in base-excision repair, AP site formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in base-excision repair, AP site formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in error-free translesion synthesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    8-oxoguanine glycosylase OGG1
    NP_013651.1
    • Nuclear and mitochondrial glycosylase/lyase; specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      151871..153001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182419.1 → NP_013651.1  TPA: 8-oxoguanine glycosylase OGG1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013651.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZB3, P53397
      UniProtKB/TrEMBL
      A0A8H4BYH0, B3LLJ5, C7GVZ6, C8ZEE5, G2WJZ5, N1NYZ7
      Conserved Domains (1) summary
      TIGR00588
      Location:1 → 328
      ogg; 8-oxoguanine DNA-glycosylase (ogg)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53397.1

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