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    CAB2 phosphopantothenate--cysteine ligase CAB2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854726, updated on 29-Jun-2024

    Summary

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    Gene symbol
    CAB2
    Gene description
    phosphopantothenate--cysteine ligase CAB2
    Primary source
    FungiDB:YIL083C
    Locus tag
    YIL083C
    See related
    SGD:S000001345; AllianceGenome:SGD:S000001345; VEuPathDB:YIL083C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphopantothenate--cysteine ligase activity. Involved in coenzyme A biosynthetic process. Located in cytoplasm and nucleus. Part of CoA-synthesizing protein complex. Used to study cancer and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human PPCS (phosphopantothenoylcysteine synthetase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CAB2 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (203556..204653, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene putative mannosyltransferase Neighboring gene Sds3p Neighboring gene gag-pol fusion protein Neighboring gene tRNA-Ile

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystallographic Analysis of the Catalytic Mechanism of Phosphopantothenoylcysteine Synthetase from Saccharomyces cerevisiae. Zheng P, et al. J Mol Biol, 2019 Feb 15. PMID 30653991
    2. Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase, Cause Autosomal-Recessive Dilated Cardiomyopathy. Iuso A, et al. Am J Hum Genet, 2018 Jun 7. PMID 29754768, Free PMC Article
    3. Molecular characterization of the heteromeric coenzyme A-synthesizing protein complex (CoA-SPC) in the yeast Saccharomyces cerevisiae. Olzhausen J, et al. FEMS Yeast Res, 2013 Sep. PMID 23789928
    4. Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1. Olzhausen J, et al. Curr Genet, 2009 Apr. PMID 19266201
    5. Increased biosynthesis of acetyl-CoA in the yeast Saccharomyces cerevisiae by overexpression of a deregulated pantothenate kinase gene and engineering of the coenzyme A biosynthetic pathway. Olzhausen J, et al. Appl Microbiol Biotechnol, 2021 Oct. PMID 34491400, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphopantothenate--cysteine ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphopantothenate--cysteine ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphopantothenate--cysteine ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in coenzyme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in coenzyme A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in coenzyme A biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CoA-synthesizing protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphopantothenate--cysteine ligase CAB2
    NP_012183.2
    • Phosphopantothenoylcysteine synthetase (PPCS); catalyzes the second step of coenzyme A biosynthesis from pantothenate; subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) that contains: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p subunits; null mutant lethality is complemented by human homolog PPCS and by E. coli coaBC, a bifunctional enzyme with PPCS activity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      203556..204653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179431.2 → NP_012183.2  TPA: phosphopantothenate--cysteine ligase CAB2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012183.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVK3, P40506
      UniProtKB/TrEMBL
      A0A6A5Q4Y1, A6ZVJ3, B3LTT1, B5VKM1, C7GKL1, C8ZAG5, G2WG68, N1P4G8
      Conserved Domains (1) summary
      COG0452
      Location:11 → 365
      CoaBC; Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40506.2

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