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    YPQ2 Ypq2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851954, updated on 29-Jun-2024

    Summary

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    Gene symbol
    YPQ2
    Gene description
    Ypq2p
    Primary source
    FungiDB:YDR352W
    Locus tag
    YDR352W
    See related
    SGD:S000002760; AllianceGenome:SGD:S000002760; VEuPathDB:YDR352W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables basic amino acid transmembrane transporter activity. Involved in basic amino acid transmembrane export from vacuole. Acts upstream of or within basic amino acid transmembrane import into vacuole. Is integral component of fungal-type vacuolar membrane. Orthologous to several human genes including SLC66A1 (solute carrier family 66 member 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YPQ2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1181801..1182754)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Atp22p Neighboring gene Sbe2p Neighboring gene thioredoxin-disulfide reductase TRR1 Neighboring gene anthranilate phosphoribosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A PQ-loop protein Ypq2 is involved in the exchange of arginine and histidine across the vacuolar membrane of Saccharomyces cerevisiae. Kawano-Kawada M, et al. Sci Rep, 2019 Oct 21. PMID 31636363, Free PMC Article
    2. Nitrogen coordinated import and export of arginine across the yeast vacuolar membrane. Cools M, et al. PLoS Genet, 2020 Aug. PMID 32776922, Free PMC Article
    3. Ypq3p-dependent histidine uptake by the vacuolar membrane vesicles of Saccharomyces cerevisiae. Manabe K, et al. Biosci Biotechnol Biochem, 2016 Jun. PMID 26928127
    4. The AP-3 adaptor complex mediates sorting of yeast and mammalian PQ-loop-family basic amino acid transporters to the vacuolar/lysosomal membrane. Llinares E, et al. Sci Rep, 2015 Nov 18. PMID 26577948, Free PMC Article
    5. Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy. Jézégou A, et al. Proc Natl Acad Sci U S A, 2012 Dec 11. PMID 23169667, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables basic amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables basic amino acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in basic amino acid transmembrane export from vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in basic amino acid transmembrane export from vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within basic amino acid transmembrane import into vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ypq2p
    NP_010639.1
    • Putative vacuolar membrane transporter for cationic amino acids; involved in vacuolar export of arginine under nitrogen starvation conditions; appears to be inactive under nitrogen replete conditions; may contribute to amino acid homeostasis; vacuolar membrane protein; member of the PQ-loop family, containing seven transmembrane domains; homologous to the human lysosomal cationic amino acid exporter PQLC2; null mutant is functionally complemented by the rat PQLC2 vacuolar transporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1181801..1182754
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180660.1 → NP_010639.1  TPA: Ypq2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010639.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSY2, Q06328
      UniProtKB/TrEMBL
      A0A8H8UNQ0, B3LFU9, B5VGN4, C7GMI2, C8Z5R3, N1PAI4
      Conserved Domains (1) summary
      pfam04193
      Location:11 → 71
      PQ-loop; PQ loop repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06328.1

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