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    AQY3 Aqy3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850490, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AQY3
    Official Full Name
    Aqy3p
    Primary source
    SGD:S000001840
    Locus tag
    YFL054C
    See related
    AllianceGenome:SGD:S000001840; FungiDB:YFL054C; VEuPathDB:YFL054C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables glycerol channel activity. Involved in transmembrane transport. Located in cell periphery. Human ortholog(s) of this gene implicated in kidney disease. Orthologous to several human genes including AQP3 (aquaporin 3 (Gill blood group)) and AQP9 (aquaporin 9). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See AQY3 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (20847..22787, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Agp3p Neighboring gene dihydroxyacetone kinase Neighboring gene DNA-binding domain containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fps1p channel is the mediator of the major part of glycerol passive diffusion in Saccharomyces cerevisiae: artefacts and re-definitions. Oliveira R, et al. Biochim Biophys Acta, 2003 Jun 27. PMID 12832087
    2. Water transport across yeast vacuolar and plasma membrane-targeted secretory vesicles occurs by passive diffusion. Coury LA, et al. J Bacteriol, 1999 Jul. PMID 10400607, Free PMC Article
    3. Aquaporin expression correlates with freeze tolerance in baker's yeast, and overexpression improves freeze tolerance in industrial strains. Tanghe A, et al. Appl Environ Microbiol, 2002 Dec. PMID 12450819, Free PMC Article
    4. The glycerol channel Fps1p mediates the uptake of arsenite and antimonite in Saccharomyces cerevisiae. Wysocki R, et al. Mol Microbiol, 2001 Jun. PMID 11442837
    5. A CRISPR/Cas9-based exploration into the elusive mechanism for lactate export in Saccharomyces cerevisiae. Mans R, et al. FEMS Yeast Res, 2017 Dec 1. PMID 29145596

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerol channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables water channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycerol transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in polyol transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in water transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Aqy3p
    NP_116601.1
    • Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      20847..22787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179913.1 → NP_116601.1  TPA: Aqy3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116601.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTH6, P43549
      UniProtKB/TrEMBL
      A6ZQC2, G2WD87, N1P6T4
      Conserved Domains (1) summary
      cd00333
      Location:348 → 557
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43549.1

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