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    CAM1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856059, updated on 11-Sep-2024

    Summary

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    Official Symbol
    CAM1
    Primary source
    SGD:S000005969
    Locus tag
    YPL048W
    See related
    AllianceGenome:SGD:S000005969; FungiDB:YPL048W; VEuPathDB:YPL048W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    TEF3
    Summary
    Enables several functions, including calcium ion binding activity; core promoter sequence-specific DNA binding activity; and guanyl-nucleotide exchange factor activity. Involved in positive regulation of transcription by RNA polymerase II; regulation of translational termination; and translational elongation. Located in nucleus. Orthologous to human EEF1G (eukaryotic translation elongation factor 1 gamma). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (464401..465648)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene mannosyltransferase complex subunit MNN9 Neighboring gene Dig1p Neighboring gene SAGA histone acetyltransferase complex subunit SGF11 Neighboring gene elongin C

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A homologue of elongation factor 1 gamma regulates methionine sulfoxide reductase A gene expression in Saccharomyces cerevisiae. Hanbauer I, et al. Proc Natl Acad Sci U S A, 2003 Jul 8. PMID 12824466, Free PMC Article
    2. Cloning and genetic characterization of a calcium- and phospholipid-binding protein from Saccharomyces cerevisiae that is homologous to translation elongation factor-1 gamma. Kambouris NG, et al. Yeast, 1993 Feb. PMID 8465602
    3. The crystal structure of the glutathione S-transferase-like domain of elongation factor 1Bgamma from Saccharomyces cerevisiae. Jeppesen MG, et al. J Biol Chem, 2003 Nov 21. PMID 12972429
    4. DRS1 to DRS7, novel genes required for ribosome assembly and function in Saccharomyces cerevisiae. Ripmaster TL, et al. Mol Cell Biol, 1993 Dec. PMID 8247005, Free PMC Article
    5. Mutations in elongation factor 1beta, a guanine nucleotide exchange factor, enhance translational fidelity. Carr-Schmid A, et al. Mol Cell Biol, 1999 Aug. PMID 10409717, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translational termination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational elongation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    translation elongation factor EF1B gamma
    NP_015277.1
    • One of two isoforms of the gamma subunit of eEF1B; stimulates the release of GDP from eEF1A (Tef1p/Tef2p) post association with the ribosomal complex with eEF1Balpha subunit; nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      464401..465648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183862.1 → NP_015277.1  TPA: translation elongation factor EF1B gamma [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015277.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3W6, P29547, Q9URC6
      UniProtKB/TrEMBL
      A6ZWK0, B3LL19, B5VTB2, C7GU06, C8ZIY1, G2WPD0, N1NW49
      Conserved Domains (3) summary
      cd03181
      Location:92 → 214
      GST_C_EF1Bgamma_like; Glutathione S-transferase C-terminal-like, alpha helical domain of the Gamma subunit of Elongation Factor 1B and similar proteins
      cd03044
      Location:4 → 73
      GST_N_EF1Bgamma; GST_N family, Gamma subunit of Elongation Factor 1B (EFB1gamma) subfamily; EF1Bgamma is part of the eukaryotic translation elongation factor-1 (EF1) complex which plays a central role in the elongation cycle during protein biosynthesis. EF1 consists of ...
      pfam00647
      Location:255 → 359
      EF1G; Elongation factor 1 gamma, conserved domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29547.2

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