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    top2 DNA topoisomerase II [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540541, updated on 14-Nov-2024

    Summary

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    Official Symbol
    top2
    Official Full Name
    DNA topoisomerase II
    Primary source
    PomBase:SPBC1A4.03c
    Locus tag
    SPOM_SPBC1A4.03C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    ptr11
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    Genomic context

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    See top2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (1976161..1981267, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene anaphase-promoting complex substrate recognition subunit Apc10 Neighboring gene ncRNA Neighboring gene 3-isopropylmalate dehydrogenase Leu1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitotic spindle pulls but fails to separate chromosomes in type II DNA topoisomerase mutants: uncoordinated mitosis. Uemura T, et al. EMBO J, 1986 May. PMID 15957215, Free PMC Article
    2. Functional dissection of the phosphorylated termini of fission yeast DNA topoisomerase II. Shiozaki K, et al. J Cell Biol, 1992 Dec. PMID 1332977, Free PMC Article
    3. The nucleotide sequence of the fission yeast DNA topoisomerase II gene: structural and functional relationships to other DNA topoisomerases. Uemura T, et al. EMBO J, 1986 Sep. PMID 3023070, Free PMC Article
    4. DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe. Uemura T, et al. Cell, 1987 Sep 11. PMID 3040264
    5. A non-canonical function of topoisomerase II in disentangling dysfunctional telomeres. Germe T, et al. EMBO J, 2009 Sep 16. PMID 19680223, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rrp2 possesses SUMO-binding ability and prevents excessive Top2 degradation by competing against the SUMO-targeted ubiquitin ligase (STUbL) for SUMO chain binding and by displacing SUMOylated Top2 from DNA.
      Title: SUMO-Targeted DNA Translocase Rrp2 Protects the Genome from Top2-Induced DNA Damage.
    2. DNA topoisomerase 2 mutant allele mildly delays the mitotic progression and activates the checkpoint protein kinase Chk1 in fission yeast Schizosaccharomyces pombe.
      Title: DNA topoisomerase 2 mutant allele mildly delays the mitotic progression and activates the checkpoint protein kinase Chk1 in fission yeast Schizosaccharomyces pombe.
    3. topoisomerase II has a role in disentangling dysfunctional telomeres
      Title: A non-canonical function of topoisomerase II in disentangling dysfunctional telomeres.
    4. Schizosaccharomyces pombe Rad32(Mre11) nuclease activity is involved in the removal of both Top2 from 5' DNA ends as well as Top1 from 3' ends in vivo and a ctp1(CtIP) deletion is defective for Top2 removal but overproficient for Top1 removal.
      Title: Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IC
    Inferred by Curator
    more info
    		 PubMed 
    enables ATP hydrolysis activity IC
    Inferred by Curator
    more info
    		  
    enables DNA binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables DNA negative supercoiling activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA topological change IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in DNA topological change IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in resolution of meiotic recombination intermediates IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromosome, centromeric core domain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear chromosome NAS
    Non-traceable Author Statement
    more info
    		  
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA topoisomerase II

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1976161..1981267 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021708.3 → NP_595805.1  DNA topoisomerase II [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595805.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74336, P08096
      Conserved Domains (7) summary
      cd03365
      Location:499 → 617
      TOPRIM_TopoIIA; TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of ...
      cd00187
      Location:741 → 1198
      TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
      cd03481
      Location:311 → 462
      TopoIIA_Trans_ScTopoIIA; TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded ...
      PTZ00108
      Location:77 → 1468
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam02518
      Location:125 → 219
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
      pfam08070
      Location:1320 → 1448
      DTHCT; DTHCT (NUC029) region
      pfam16898
      Location:615 → 741
      TOPRIM_C; C-terminal associated domain of TOPRIM
    Nucleotide Protein
    Heading Accession and Version

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