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    reb1 RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539930, updated on 18-Sep-2024

    Summary

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    Official Symbol
    reb1
    Official Full Name
    RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1
    Primary source
    PomBase:SPBC1198.11c
    Locus tag
    SPOM_SPBC1198.11C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPBC660.01c
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    Genomic context

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    See reb1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (191752..193609, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene dipeptidase Dug1 Neighboring gene asparagine--tRNA (Asn) ligase Slm5 Neighboring gene ubiquitin conjugating enzyme Ubc16 Neighboring gene ncRNA Neighboring gene transcription factor TFIIF complex beta subunit Tfg2 Neighboring gene ubiquitin ligase Mfr1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcription termination factor reb1p causes two replication fork barriers at its cognate sites in fission yeast ribosomal DNA in vivo. Sánchez-Gorostiaga A, et al. Mol Cell Biol, 2004 Jan. PMID 14673172, Free PMC Article
    2. Crystallization and preliminary X-ray characterization of the eukaryotic replication terminator Reb1-Ter DNA complex. Jaiswal R, et al. Acta Crystallogr F Struct Biol Commun, 2015 Apr. PMID 25849502, Free PMC Article
    3. Molecular cloning and analysis of Schizosaccharomyces pombe Reb1p: sequence-specific recognition of two sites in the far upstream rDNA intergenic spacer. Zhao A, et al. Nucleic Acids Res, 1997 Feb 15. PMID 9016645, Free PMC Article
    4. Mechanistic insights into replication termination as revealed by investigations of the Reb1-Ter3 complex of Schizosaccharomyces pombe. Biswas S, et al. Mol Cell Biol, 2008 Nov. PMID 18794373, Free PMC Article
    5. Regulation of replication termination by Reb1 protein-mediated action at a distance. Singh SK, et al. Cell, 2010 Sep 17. PMID 20850009, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional architecture of the Reb1-Ter complex of Schizosaccharomyces pombe.
      Title: Functional architecture of the Reb1-Ter complex of Schizosaccharomyces pombe.
    2. Reb1 acts as a link between rDNA metabolism and cell cycle control in response to nutritional stress.
      Title: The fission yeast rDNA-binding protein Reb1 regulates G1 phase under nutritional stress.
    3. Study shows that Reb1-dependent Ter sites of S. pombe do not function solely in isolation but communicate pairwise with other such sites either by DNA looping or by chromosome kissing to regulate the magnitude of physiologically programmed fork arrest.
      Title: Regulation of replication termination by Reb1 protein-mediated action at a distance.
    4. These observations suggest that replication fork arrest is not an intrinsic property of the Reb1-Ter3 complex.
      Title: Mechanistic insights into replication termination as revealed by investigations of the Reb1-Ter3 complex of Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables rDNA spacer replication fork barrier binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables rDNA spacer replication fork barrier binding, bending IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription termination site sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cis-acting DNA replication termination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork arrest IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replication fork arrest at rDNA repeats IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replication fork arrest involved in DNA replication termination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in termination of RNA polymerase I transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in termination of RNA polymerase I transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleolar peripheral inclusion body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in rDNA heterochromatin EXP
    Inferred from Experiment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      191752..193609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356228.2 → NP_001342963.1  RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94422, Q9P6H9
      Conserved Domains (1) summary
      COG5147
      Location:2 → 504
      REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version

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