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    srb10 mediator complex cyclin-dependent protein kinase subunit Srb10 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541900, updated on 18-Sep-2024

    Summary

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    Official Symbol
    srb10
    Official Full Name
    mediator complex cyclin-dependent protein kinase subunit Srb10
    Primary source
    PomBase:SPAC23H4.17c
    Locus tag
    SPOM_SPAC23H4.17C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    cdk8; prk1
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    Genomic context

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    See srb10 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (1576707..1578028)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SCF complex, Cul4-RING and CLRC ubiquitin ligase ligase E3 subunit Rbx1 Neighboring gene ncRNA Neighboring gene protein Not11 Neighboring gene ncRNA Neighboring gene ribosome biogenesis protein Tsr1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LAMMER Kinase Lkh1 Is an Upstream Regulator of Prk1-Mediated Non-Sexual Flocculation in Fission Yeast. Park YD, et al. Mycobiology, 2018. PMID 30294483, Free PMC Article
    2. Structure of the mediator subunit cyclin C and its implications for CDK8 function. Hoeppner S, et al. J Mol Biol, 2005 Jul 29. PMID 15979093
    3. Structure of Ctk3, a subunit of the RNA polymerase II CTD kinase complex, reveals a noncanonical CTD-interacting domain fold. Mühlbacher W, et al. Proteins, 2015 Oct. PMID 26219431
    4. Mediator can regulate mitotic entry and direct periodic transcription in fission yeast. Banyai G, et al. Mol Cell Biol, 2014 Nov. PMID 25154415, Free PMC Article
    5. Cyclin-dependent kinase 8 regulates mitotic commitment in fission yeast. Szilagyi Z, et al. Mol Cell Biol, 2012 Jun. PMID 22451489, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Mediator subunit cyclin-dependent kinase 8 (Cdk8) phosphorylates the forkhead 2 (Fkh2) protein in a periodic manner that coincides with gene activation during mitosis
      Title: Cyclin-dependent kinase 8 regulates mitotic commitment in fission yeast.
    2. Data demonstrated that Mediator regulates Cdk8 activity and mutations in the complex can both speed up and delay entry into mitosis.
      Title: Mediator can regulate mitotic entry and direct periodic transcription in fission yeast.
    3. The crystal structure of cyclin C is reported, and a model of the cyclin-dependent kinase 8 (CDK8)/cyclin C pair is presented. An alternative mechanism of CDK8 activation based on the CDK8/cyclin C model is discussed. [CDK8]
      Title: Structure of the mediator subunit cyclin C and its implications for CDK8 function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables RNA polymerase II CTD heptapeptide repeat S5 kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mediator complex cyclin-dependent protein kinase subunit Srb10

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1576707..1578028
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018821.3 → NP_593389.2  mediator complex cyclin-dependent protein kinase subunit Srb10 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593389.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13958
      Conserved Domains (2) summary
      PTZ00024
      Location:1 → 324
      PTZ00024; cyclin-dependent protein kinase; Provisional
      cd07842
      Location:4 → 319
      STKc_CDK8_like; Catalytic domain of Cyclin-Dependent protein Kinase 8-like Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version

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