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    CBS1 Cbs1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851491, updated on 17-May-2024

    Summary

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    Gene symbol
    CBS1
    Gene description
    Cbs1p
    Primary source
    FungiDB:YDL069C
    Locus tag
    YDL069C
    See related
    SGD:S000002227; AllianceGenome:SGD:S000002227; VEuPathDB:YDL069C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables translation regulator activity. Involved in mitochondrial respiratory chain complex III assembly and positive regulation of mitochondrial translation. Located in mitochondrial ribosome. Is extrinsic component of mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CBS1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (333121..333810, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Yet3p Neighboring gene Bdf2p Neighboring gene cytochrome c oxidase subunit VIIa Neighboring gene isocitrate dehydrogenase (NADP(+)) IDP1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae translational activator Cbs1p is associated with translationally active mitochondrial ribosomes. Krause-Buchholz U, et al. Biol Chem, 2005 May. PMID 15927884
    2. Identification of functionally important regions of the Saccharomyces cerevisiae mitochondrial translational activator Cbs1p. Krause-Buchholz U, et al. Yeast, 2000 Mar 15. PMID 10669873
    3. Genetic strategies for identification of mitochondrial translation factors in Saccharomyces cerevisiae. Fox TD. Methods Enzymol, 1996. PMID 8965696
    4. The yeast nuclear gene CBS1 is required for translation of mitochondrial mRNAs bearing the cob 5' untranslated leader. Rödel G, et al. Mol Gen Genet, 1987 Jan. PMID 3033440
    5. In vitro and in vivo studies on the mitochondrial import of CBS1, a translational activator of cytochrome b in yeast. Körte A, et al. Mol Gen Genet, 1989 May. PMID 2671648

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables translation regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex III assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial ribosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cbs1p
    NP_010214.2
    • Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      333121..333810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180128.1 → NP_010214.2  TPA: Cbs1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010214.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRS9, P14066
      UniProtKB/TrEMBL
      A0A8H8UML5, B3LGW5, C7GJP2, C8Z4K0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14066.2

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