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    PHM8 bifunctional nucleotidase/lysophosphatidic acid phosphatase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856759, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PHM8
    Official Full Name
    bifunctional nucleotidase/lysophosphatidic acid phosphatase
    Primary source
    SGD:S000000839
    Locus tag
    YER037W
    See related
    AllianceGenome:SGD:S000000839; FungiDB:YER037W; VEuPathDB:YER037W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables lysophosphatidic acid phosphatase activity and nucleotidase activity. Involved in nucleotide catabolic process; response to starvation; and triglyceride homeostasis. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PHM8 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (225889..226854)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Edc2p Neighboring gene ATP-binding cassette family ATPase ARB1 Neighboring gene Smc5-Smc6 complex subunit KRE29 Neighboring gene Fmp49p Neighboring gene putative GDP-mannose transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Saccharomyces cerevisiae PHM8 gene encodes a soluble magnesium-dependent lysophosphatidic acid phosphatase. Reddy VS, et al. J Biol Chem, 2008 Apr 4. PMID 18234677
    2. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Gray NS, et al. Science, 1998 Jul 24. PMID 9677190
    3. The transcription factor GCN4 regulates PHM8 and alters triacylglycerol metabolism in Saccharomyces cerevisiae. Yadav KK, et al. Curr Genet, 2016 Nov. PMID 26979516
    4. PHO4 transcription factor regulates triacylglycerol metabolism under low-phosphate conditions in Saccharomyces cerevisiae. Yadav KK, et al. Mol Microbiol, 2015 Oct. PMID 26179227
    5. Nucleotide degradation and ribose salvage in yeast. Xu YF, et al. Mol Syst Biol, 2013 May 14. PMID 23670538, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we investigated the role of PHM8 in triacylglycerol metabolism and its transcriptional regulation by a phosphate responsive transcription factor Pho4p under low-phosphate conditions.
      Title: PHO4 transcription factor regulates triacylglycerol metabolism under low-phosphate conditions in Saccharomyces cerevisiae.
    2. The Saccharomyces cerevisiae PHM8 gene encodes a soluble magnesium-dependent lysophosphatidic acid phosphatase.
      Title: The Saccharomyces cerevisiae PHM8 gene encodes a soluble magnesium-dependent lysophosphatidic acid phosphatase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophosphatidic acid phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lysophosphatidic acid phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to phosphate starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pyrimidine nucleobase metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to carbon starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    bifunctional nucleotidase/lysophosphatidic acid phosphatase
    NP_010954.1
    • Lysophosphatidic acid (LPA) phosphatase, nucleotidase; principle and physiological nucleotidase working on GMP, UMP and CMP; involved in LPA hydrolysis in response to phosphate starvation and ribose salvage pathway; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p; repressed by Gcn4p under normal conditions; PHM8 has a paralog, SDT1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      225889..226854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178928.1 → NP_010954.1  TPA: bifunctional nucleotidase/lysophosphatidic acid phosphatase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010954.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLT6, P40025
      UniProtKB/TrEMBL
      A6ZQY6, B3LS49, B5VHH3, C7GSI3, C8Z739, G2WCS0, N1P3B7
      Conserved Domains (1) summary
      cd02604
      Location:54 → 250
      HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to Saccharomyces cerevisiae Phm8p and Sdt1p
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40025.1

    Gene LinkOut

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