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    MIC12 Mic12p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852566, updated on 29-Jun-2024

    Summary

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    Gene symbol
    MIC12
    Gene description
    Mic12p
    Primary source
    FungiDB:YBR262C
    Locus tag
    YBR262C
    See related
    SGD:S000000466; AllianceGenome:SGD:S000000466; VEuPathDB:YBR262C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AIM5; FMP51; MCS12
    Summary
    Involved in cellular protein-containing complex assembly and cristae formation. Located in mitochondrial crista junction. Part of MICOS complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MIC12 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (735720..736040, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene GTPase-activating protein RGD1 Neighboring gene N-terminal protein methyltransferase Neighboring gene glycine hydroxymethyltransferase SHM1 Neighboring gene Rab family GTPase YPT10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mic60 exhibits a coordinated clustered distribution along and across yeast and mammalian mitochondria. Stoldt S, et al. Proc Natl Acad Sci U S A, 2019 May 14. PMID 31028145, Free PMC Article
    2. Distinct Roles of Mic12 and Mic27 in the Mitochondrial Contact Site and Cristae Organizing System. Zerbes RM, et al. J Mol Biol, 2016 Apr 24. PMID 26968360
    3. Myristoyl group-aided protein import into the mitochondrial intermembrane space. Ueda E, et al. Sci Rep, 2019 Feb 4. PMID 30718713, Free PMC Article
    4. Aim24 and MICOS modulate respiratory function, tafazzin-related cardiolipin modification and mitochondrial architecture. Harner ME, et al. Elife, 2014 Jan 1. PMID 24714493, Free PMC Article
    5. Mitochondrial contact site and cristae organizing system (MICOS) machinery supports heme biosynthesis by enabling optimal performance of ferrochelatase. Dietz JV, et al. Redox Biol, 2021 Oct. PMID 34517185, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. in addition to the MICOS core components Mic10 and Mic60, Mic12 and Mic27 play specific roles in the organization of the MICOS complex
      Title: Distinct Roles of Mic12 and Mic27 in the Mitochondrial Contact Site and Cristae Organizing System.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cristae formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cristae formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MICOS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of MICOS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial crista junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial crista junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mic12p
    NP_009821.3
    • Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; forms a subcomplex with Mic10p and Mic27p whose assembly and stability requires cardiolipin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      735720..736040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178610.3 → NP_009821.3  TPA: Mic12p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009821.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZLK2, B3LMP9, C7GMW8, D3UF10, D6VQQ9, P38341
      UniProtKB/TrEMBL
      A0A6A5Q5L3, G2W9R7, N1P9M8
      Conserved Domains (1) summary
      pfam17050
      Location:79 → 102
      AIM5; Altered inheritance of mitochondria 5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38341.1

    Gene LinkOut

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