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    ubp5 ubiquitin hydrolase Ubp5 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539385, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ubp5
    Official Full Name
    ubiquitin hydrolase Ubp5
    Primary source
    PomBase:SPCC188.08c
    Locus tag
    SPOM_SPCC188.08C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See ubp5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003421.2 (1488553..1492479, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene shelterin complex HEAT repeat subunit Ccq1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene flocculin Pfl4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The deubiquitinating enzyme Ubp21p of fission yeast stabilizes a mutant form of protein kinase Prp4p. Richert K, et al. Mol Genet Genomics, 2002 Mar. PMID 11919719
    2. A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival. Beckley JR, et al. Mol Cell Proteomics, 2015 Dec. PMID 26412298, Free PMC Article
    3. A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity. Kouranti I, et al. PLoS Biol, 2010 Sep 7. PMID 20838651, Free PMC Article
    4. Sde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing. Thakran P, et al. EMBO J, 2018 Jan 4. PMID 28947618, Free PMC Article
    5. A central role for TOR signalling in a yeast model for juvenile CLN3 disease. Bond ME, et al. Microb Cell, 2015 Nov 11. PMID 28357272, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal-dependent deubiquitinase activity HDA PubMed 
    enables metal-dependent deubiquitinase activity HMP PubMed 
    enables metal-dependent deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus HDA PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin hydrolase Ubp5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1488553..1492479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023201.3 → NP_588211.1  ubiquitin hydrolase Ubp5 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588211.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q09879, Q10433, Q9Y7P5
      Conserved Domains (5) summary
      COG5077
      Location:15 → 1107
      COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02659
      Location:211 → 530
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd03775
      Location:56 → 188
      MATH_Ubp21p; Ubiquitin-specific protease 21 (Ubp21p) family, MATH domain; composed of fungal proteins with similarity to Ubp21p of fission yeast. Ubp21p is a deubiquitinating enzyme that may be involved in the regulation of the protein kinase Prp4p, which controls ...
      pfam12436
      Location:631 → 881
      USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7
      pfam14533
      Location:892 → 1092
      USP7_C2; Ubiquitin-specific protease C-terminal
    Nucleotide Protein
    Heading Accession and Version

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