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    ROG3 Rog3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850578, updated on 17-May-2024

    Summary

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    Gene symbol
    ROG3
    Gene description
    Rog3p
    Primary source
    FungiDB:YFR022W
    Locus tag
    YFR022W
    See related
    SGD:S000001918; AllianceGenome:SGD:S000001918; VEuPathDB:YFR022W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ART7
    Summary
    Enables ubiquitin protein ligase binding activity. Involved in adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion and positive regulation of receptor internalization. Located in cytosol. Orthologous to human ARRDC2 (arrestin domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ROG3 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (196833..199034)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Css2p Neighboring gene phosphoinositide binding protein ATG18 Neighboring gene ncRNA Neighboring gene Pes4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tracking yeast pheromone receptor Ste2 endocytosis using fluorogen-activating protein tagging. Emmerstorfer-Augustin A, et al. Mol Biol Cell, 2018 Nov 1. PMID 30207829, Free PMC Article
    2. PY motifs of Rod1 are required for binding to Rsp5 and for drug resistance. Andoh T, et al. FEBS Lett, 2002 Aug 14. PMID 12163175
    3. 2-Deoxyglucose impairs Saccharomyces cerevisiae growth by stimulating Snf1-regulated and α-arrestin-mediated trafficking of hexose transporters 1 and 3. O'Donnell AF, et al. Mol Cell Biol, 2015 Mar. PMID 25547292, Free PMC Article
    4. Differential Phosphorylation Provides a Switch to Control How α-Arrestin Rod1 Down-regulates Mating Pheromone Response in Saccharomyces cerevisiae. Alvaro CG, et al. Genetics, 2016 May. PMID 26920760, Free PMC Article
    5. Rsp5-dependent endocytosis and degradation of the arsenite transporter Acr3 requires its N-terminal acidic tail as an endocytic sorting signal and arrestin-related ubiquitin-ligase adaptors. Wawrzycka D, et al. Biochim Biophys Acta Biomembr, 2019 May 1. PMID 30776335

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data shows that Rog3 is required for Ste2 efficient internalization.
      Title: Specific α-arrestins negatively regulate Saccharomyces cerevisiae pheromone response by down-modulating the G-protein-coupled receptor Ste2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to pheromone IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to pheromone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in conjugation with cellular fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of receptor internalization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ubiquitin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rog3p
    NP_116677.3
    • Alpha-arrestin involved in ubiquitin-dependent endocytosis; contributes to desensitization of agonist-occupied alpha-factor receptor Ste2p by Rsp5p-independent internalization; PPXY motif-mediated binding of the ubiquitin ligase Rsp5p is not required for adaptation; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; SWAT-GFP and mCherry fusion proteins localize to the cytosol; ROG3 has a paralog, ROD1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      196833..199034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179987.3 → NP_116677.3  TPA: Rog3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116677.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTQ2, P43602
      UniProtKB/TrEMBL
      A0A8H8ULA5, N1P508
      Conserved Domains (2) summary
      smart01017
      Location:232 → 393
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:156 → 215
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43602.1

    Gene LinkOut

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