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    CHA4 Cha4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850787, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CHA4
    Official Full Name
    Cha4p
    Primary source
    SGD:S000004088
    Locus tag
    YLR098C
    See related
    AllianceGenome:SGD:S000004088; FungiDB:YLR098C; VEuPathDB:YLR098C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SIL2; SIL3
    Summary
    Enables DNA-binding transcription factor activity. Involved in cellular amino acid catabolic process and positive regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CHA4 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (337527..339473, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase KIN2 Neighboring gene SCF ubiquitin ligase complex subunit HRT3 Neighboring gene lysophosphatidic acid acyltransferase ICT1 Neighboring gene Mim2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cha4p of Saccharomyces cerevisiae activates transcription via serine/threonine response elements. Holmberg S, et al. Genetics, 1996 Oct. PMID 8889513, Free PMC Article
    2. Yeast transcriptional regulator Leu3p. Self-masking, specificity of masking, and evidence for regulation by the intracellular level of Leu3p. Wang D, et al. J Biol Chem, 1999 Jul 2. PMID 10383402
    3. Sphingoid bases and the serine catabolic enzyme CHA1 define a novel feedforward/feedback mechanism in the response to serine availability. Montefusco DJ, et al. J Biol Chem, 2012 Mar 16. PMID 22277656, Free PMC Article
    4. Adaptation, chance, and history in experimental evolution reversals to unicellularity. Rebolleda-Gómez M, et al. Evolution, 2019 Jan. PMID 30520011, Free PMC Article
    5. Molecular genetics of serine and threonine catabolism in Saccharomyces cerevisiae. Petersen JG, et al. Genetics, 1988 Jul. PMID 2841185, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding HDA PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cha4p
    NP_013199.1
    • DNA binding transcriptional activator; mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      337527..339473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181985.1 → NP_013199.1  TPA: Cha4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013199.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY98, P43634
      UniProtKB/TrEMBL
      G2WIU1
      Conserved Domains (2) summary
      pfam00172
      Location:43 → 78
      Zn_clus; Fungal Zn(2)-Cys(6) binuclear cluster domain
      pfam04082
      Location:214 → 473
      Fungal_trans; Fungal specific transcription factor domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43634.1

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