U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    VPS74 Vps74p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851978, updated on 2-Nov-2024

    Summary

    Official Symbol
    VPS74
    Official Full Name
    Vps74p
    Primary source
    SGD:S000002780
    Locus tag
    YDR372C
    See related
    AllianceGenome:SGD:S000002780; FungiDB:YDR372C; VEuPathDB:YDR372C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    API1; MNN3
    Summary
    Enables enzyme binding activity and phosphatidylinositol-4-phosphate binding activity. Involved in several processes, including endoplasmic reticulum unfolded protein response; protein retention in Golgi apparatus; and regulation of phosphatidylinositol dephosphorylation. Located in Golgi medial cisterna and cytosol. Orthologous to several human genes including GOLPH3L (golgi phosphoprotein 3 like). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See VPS74 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1221112..1222149, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Dxo1p Neighboring gene putative chitinase Neighboring gene frequenin Neighboring gene mRNA-binding phosphate metabolism regulator

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-4-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol-4-phosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-4-phosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-4-phosphate binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in Golgi cisterna IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi medial cisterna IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Vps74p
    NP_010660.1
    • Golgi PI4K effector, PtdIns4P sensor, and retention receptor; interacts with glycosyltransferases, and in the PtdIns4P-bound state mediates retention of these enzymes in the Golgi; PtdIns4P sensor that limits PI4K signaling and regulates lipid homeostasis, interacting with the catalytic domain of Sac1p, the major PtdIns4P phosphatase, directing dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; contributes to telomere function; ortholog of human GOLPH3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1221112..1222149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180680.1NP_010660.1  TPA: Vps74p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010660.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT03, Q06385
      UniProtKB/TrEMBL
      A6ZYX0, B3LFT1, B5VGQ2, C7GMG5, N1PAI8
      Conserved Domains (1) summary
      pfam05719
      Location:69290
      GPP34; Golgi phosphoprotein 3 (GPP34)