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    uncharacterized protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852354, updated on 18-Sep-2024

    Summary

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    Official Full Name
    uncharacterized protein
    Primary source
    SGD:S000000266
    Locus tag
    YBR062C
    See related
    AllianceGenome:SGD:S000000266; FungiDB:YBR062C; VEuPathDB:YBR062C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Human ortholog(s) of this gene implicated in Tonne-Kalscheuer syndrome. Orthologous to human PJA2 (praja ring finger ubiquitin ligase 2) and RLIM (ring finger protein, LIM domain interacting). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_001134.8 (365976..366600, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene origin recognition complex subunit 2 Neighboring gene tRNA methyltransferase TRM7 Neighboring gene Cnm1p Neighboring gene Ecm2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Forcing interactions as a genetic screen to identify proteins that exert a defined activity. Devit M, et al. Genome Res, 2005 Apr. PMID 15805496, Free PMC Article
    2. The ubiquitin-proteasome system regulates meiotic chromosome organization. Yang X, et al. Proc Natl Acad Sci U S A, 2022 Apr 26. PMID 35439061, Free PMC Article
    3. Complete DNA sequence of yeast chromosome II. Feldmann H, et al. EMBO J, 1994 Dec 15. PMID 7813418, Free PMC Article
    4. The cellular economy of the Saccharomyces cerevisiae zinc proteome. Wang Y, et al. Metallomics, 2018 Dec 12. PMID 30358795, Free PMC Article
    5. Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches. McClellan AJ, et al. Cell, 2007 Oct 5. PMID 17923092

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_009618.2
    • hypothetical protein that interacts with Msb2p; may play a role in activation of the filamentous growth pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      365976..366600 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178410.1 → NP_009618.2  TPA: uncharacterized protein YBR062C [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009618.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ62, P38239
      UniProtKB/TrEMBL
      G2W968, N1P818
      Conserved Domains (2) summary
      cd00162
      Location:109 → 152
      RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
      cl17238
      Location:109 → 153
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38239.2

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