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    los1 karyopherin exportin-T Los1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541311, updated on 18-Sep-2024

    Summary

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    Official Symbol
    los1
    Official Full Name
    karyopherin exportin-T Los1
    Primary source
    PomBase:SPBP8B7.09c
    Locus tag
    SPOM_SPBP8B7.09C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See los1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (3647074..3650159, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene histone lysine methyltransferase Set6 Neighboring gene leucine carboxyl methyltransferase Ppm1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene U3 snoRNP-associated protein Utp16 Neighboring gene ncRNA Neighboring gene ubiquitin protease cofactor Nxt3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structures of the tRNA export factor in the nuclear and cytosolic states. Cook AG, et al. Nature, 2009 Sep 3. PMID 19680239
    2. Altered nuclear tRNA metabolism in La-deleted Schizosaccharomyces pombe is accompanied by a nutritional stress response involving Atf1p and Pcr1p that is suppressible by Xpo-t/Los1p. Cherkasova V, et al. Mol Biol Cell, 2012 Feb. PMID 22160596, Free PMC Article
    3. Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries. Wang J, et al. Genes Dev, 2013 Sep 1. PMID 24013502, Free PMC Article
    4. A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors. Chen Z, et al. G3 (Bethesda), 2012 Oct. PMID 23050226, Free PMC Article
    5. Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts. Anver S, et al. EMBO Rep, 2014 Aug. PMID 24957674, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables GTP binding NAS
    Non-traceable Author Statement
    more info
    		  
    enables nuclear export signal receptor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA export from nucleus EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in tRNA re-export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nuclear envelope HDA PubMed 
    is_active_in nuclear matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    karyopherin exportin-T Los1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3647074..3650159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022437.3 → NP_596516.1  karyopherin exportin-T Los1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596516.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94258
      Conserved Domains (1) summary
      pfam08389
      Location:120 → 253
      Xpo1; Exportin 1-like protein
    Nucleotide Protein
    Heading Accession and Version

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