ORC5 origin recognition complex subunit 5 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: ORC5
Gene description: origin recognition complex subunit 5
Primary source: FungiDB:YNL261W
Locus tag: YNL261W
See related: SGD:S000005205; AllianceGenome:SGD:S000005205; VEuPathDB:YNL261W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ATP binding activity and DNA replication origin binding activity. Involved in DNA replication initiation; pre-replicative complex assembly involved in nuclear cell cycle DNA replication; and silent mating-type cassette heterochromatin assembly. Part of DNA replication preinitiation complex; nuclear origin of replication recognition complex; and nuclear pre-replicative complex. Orthologous to human ORC5 (origin recognition complex subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ORC5 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (155100..156539)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

our findings suggest a role of Rrm3, via its Orc5-binding domain, in restricting DNA synthesis that is genetically and physically separable from its established catalytic role in facilitating fork progression through replication blocks.
Title: A Novel Rrm3 Function in Restricting DNA Replication via an Orc5-Binding Domain Is Genetically Separable from Rrm3 Function as an ATPase/Helicase in Facilitating Fork Progression.
In this study, yeast two-hybrid analysis was used to examine the interaction between Cdt1p and every ORC subunit; potent interaction with Orc6p, and weaker interaction with Orc2p and Orc5p was observed.
Title: Interaction between ORC and Cdt1p of Saccharomyces cerevisiae.
interaction is mediated by the C-terminal region of Orc4p, and the N-terminal region of Orc5p
Title: Mechanism for the degradation of origin recognition complex containing Orc5p with a defective Walker A motif and its suppression by over-production of Orc4p in yeast cells.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA replication origin binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA replication origin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication initiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in DNA replication initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pre-replicative complex assembly involved in nuclear cell cycle DNA replication	IDA Inferred from Direct Assay more info	PubMed
involved_in silent mating-type cassette heterochromatin formation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of DNA replication preinitiation complex	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear origin of replication recognition complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear origin of replication recognition complex	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear origin of replication recognition complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of nuclear pre-replicative complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of origin recognition complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: origin recognition complex subunit 5

NP_014138.1

Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

155100..156539

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183099.1 → NP_014138.1 TPA: origin recognition complex subunit 5 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014138.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0T2, P50874

UniProtKB/TrEMBL

A0A8H4BXR4, A6ZRI2, B3LPA3, B5VQF0, C8ZFX7

Conserved Domains (2) summary

pfam13191
Location:11 → 146

AAA_16; AAA ATPase domain

pfam14630
Location:189 → 474

ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus