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    SAG1 Sag1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853460, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SAG1
    Official Full Name
    Sag1p
    Primary source
    SGD:S000003764
    Locus tag
    YJR004C
    See related
    AllianceGenome:SGD:S000003764; FungiDB:YJR004C; VEuPathDB:YJR004C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AG(ALPHA)1
    Summary
    Enables cell adhesion molecule binding activity. Involved in agglutination involved in conjugation with cellular fusion. Located in fungal-type cell wall. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SAG1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (442909..444861, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene rRNA-processing protein MPP10 Neighboring gene Mrx12p Neighboring gene Apl1p Neighboring gene Lso1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High-throughput characterization of protein-protein interactions by reprogramming yeast mating. Younger D, et al. Proc Natl Acad Sci U S A, 2017 Nov 14. PMID 29087945, Free PMC Article
    2. An α-mating-type-specific mutation causing specific defect in sexual agglutinability in the yeast Saccharomyces cerevisiae. Suzuki K, et al. Curr Genet, 1985 Mar. PMID 24173552
    3. The molecular basis of sex: linking yeast to human. Swanson WJ, et al. Mol Biol Evol, 2011 Jul. PMID 21282709, Free PMC Article
    4. Environmentally induced reversible conformational switching in the yeast cell adhesion protein alpha-agglutinin. Zhao H, et al. Protein Sci, 2001 Jun. PMID 11369849, Free PMC Article
    5. A CD2-based model of yeast alpha-agglutinin elucidates solution properties and binding characteristics. Grigorescu A, et al. IUBMB Life, 2000 Aug. PMID 11185954

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in agglutination involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sag1p
    NP_012537.1
    • Alpha-agglutinin of alpha-cells; binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      442909..444861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181661.1 → NP_012537.1  TPA: Sag1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012537.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWH8, P20840
      UniProtKB/TrEMBL
      B3LQA2, D3UF71, N1P100
      Conserved Domains (1) summary
      smart01056
      Location:50 → 300
      Candida_ALS_N; Cell-wall agglutinin N-terminal ligand-sugar binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20840.2

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