HMX1 Hmx1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: HMX1
Gene description: Hmx1p
Primary source: FungiDB:YLR205C
Locus tag: YLR205C
See related: SGD:S000004195; AllianceGenome:SGD:S000004195; VEuPathDB:YLR205C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables heme oxygenase (decyclizing) activity. Involved in cellular iron ion homeostasis; heme catabolic process; and response to oxidative stress. Located in endoplasmic reticulum and nuclear outer membrane. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); factor VIII deficiency; lung disease (multiple); and sickle cell anemia. Orthologous to human HMOX1 (heme oxygenase 1) and HMOX2 (heme oxygenase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The yeast homolog of heme oxygenase-1 affords cellular antioxidant protection via the transcriptional regulation of known antioxidant genes.
Title: The yeast homolog of heme oxygenase-1 affords cellular antioxidant protection via the transcriptional regulation of known antioxidant genes.
Data show that the metabolic cyle exhibited by the Deltahmx1 strain are approximately 4.5 h, approximately 25% longer than WT.
Title: Evidence of carbon monoxide-mediated phase advancement of the yeast metabolic cycle.
One of the first fungal heme oxygenases to be heterologously overexpressed and characterized.
Title: Fungal heme oxygenases: Functional expression and characterization of Hmx1 from Saccharomyces cerevisiae and CaHmx1 from Candida albicans.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables heme oxygenase (decyclizing) activity	IDA Inferred from Direct Assay more info	PubMed
enables heme oxygenase (decyclizing) activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in heme catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heme oxidation	IEA Inferred from Electronic Annotation more info
involved_in intracellular iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear outer membrane	IDA Inferred from Direct Assay more info	PubMed

NP_013306.2

ER localized heme oxygenase; involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants

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