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    PSF2 DNA replication protein PSF2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853373, updated on 6-Oct-2024

    Summary

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    Official Symbol
    PSF2
    Official Full Name
    DNA replication protein PSF2
    Primary source
    SGD:S000003608
    Locus tag
    YJL072C
    See related
    AllianceGenome:SGD:S000003608; FungiDB:YJL072C; VEuPathDB:YJL072C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CDC102
    Summary
    Involved in DNA-dependent DNA replication and double-strand break repair via break-induced replication. Located in nuclear replication fork. Part of CMG complex; GINS complex; and replication fork protection complex. Orthologous to human GINS2 (GINS complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PSF2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (305221..305862, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene cohesin subunit SMC3 Neighboring gene Jem1p Neighboring gene acetyl-CoA:L-glutamate N-acetyltransferase Neighboring gene metallo-dependent hydrolase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mcm10 plays a role in functioning of the eukaryotic replicative DNA helicase, Cdc45-Mcm-GINS. Watase G, et al. Curr Biol, 2012 Feb 21. PMID 22285032
    2. Distinct roles for Sld3 and GINS during establishment and progression of eukaryotic DNA replication forks. Kanemaki M, et al. EMBO J, 2006 Apr 19. PMID 16601689, Free PMC Article
    3. Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo. Kanemaki M, et al. Nature, 2003 Jun 12. PMID 12768207
    4. The replication initiation protein Sld2 regulates helicase assembly. Bruck I, et al. J Biol Chem, 2014 Jan 24. PMID 24307213, Free PMC Article
    5. Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork. Calzada A, et al. Genes Dev, 2005 Aug 15. PMID 16103218, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in DNA-templated DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via break-induced replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CMG complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of DNA replication preinitiation complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of GINS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GINS complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nuclear chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear replication fork IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-DNA complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of replication fork protection complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA replication protein PSF2
    NP_012463.1
    • Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      305221..305862 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181505.1 → NP_012463.1  TPA: DNA replication protein PSF2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012463.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWB1, P40359
      UniProtKB/TrEMBL
      A6ZPQ1, B3LQ39, B5VLA6, C7GR41, D3UF61, G2WGU5, N1P0U5
      Conserved Domains (1) summary
      COG5093
      Location:1 → 199
      COG5093; Uncharacterized conserved protein [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40359.1

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