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    SAY1 steryl deacetylase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853179, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SAY1
    Official Full Name
    steryl deacetylase
    Primary source
    SGD:S000003495
    Locus tag
    YGR263C
    See related
    AllianceGenome:SGD:S000003495; FungiDB:YGR263C; VEuPathDB:YGR263C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables steryl deacetylase activity. Involved in response to toxic substance and sterol deacetylation. Located in endoplasmic reticulum lumen and lipid droplet. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SAY1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (1017967..1019241, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Apl6p Neighboring gene serine/threonine protein kinase BUD32 Neighboring gene methionine--tRNA ligase MES1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of an 11.6 kb region from the right arm of chromosome VII of Saccharomyces cerevisiae between the RAD2 and the MES1 genes reveals the presence of three new genes. Clemente ML, et al. Yeast, 1997 Mar 15. PMID 9090059
    2. An acetylation/deacetylation cycle controls the export of sterols and steroids from S. cerevisiae. Tiwari R, et al. EMBO J, 2007 Dec 12. PMID 18034159, Free PMC Article
    3. Prostate secretory protein 94 inhibits sterol binding and export by the mammalian CAP protein CRISP2 in a calcium-sensitive manner. El Atab O, et al. J Biol Chem, 2022 Mar. PMID 35063506, Free PMC Article
    4. High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation. Currie E, et al. J Lipid Res, 2014 Jul. PMID 24868093, Free PMC Article
    5. Systematic analysis of membrane contact sites in Saccharomyces cerevisiae uncovers modulators of cellular lipid distribution. Castro IG, et al. Elife, 2022 Nov 10. PMID 36354737, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables steryl deacetylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables steryl deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    steryl deacetylase
    NP_011779.3
    • Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; active both in the endoplasmic reticulum (ER) and in lipid droplets; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the ER

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      1017967..1019241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181392.3 → NP_011779.3  TPA: steryl deacetylase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011779.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV42, P53324
      UniProtKB/TrEMBL
      B3LHX9, B5VJK5, C8Z9F5, N1P690
      Conserved Domains (1) summary
      pfam10340
      Location:50 → 421
      Say1_Mug180; Steryl acetyl hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53324.1

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