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    ARX1 putative hydrolase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851678, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ARX1
    Official Full Name
    putative hydrolase
    Primary source
    SGD:S000002508
    Locus tag
    YDR101C
    See related
    AllianceGenome:SGD:S000002508; FungiDB:YDR101C; VEuPathDB:YDR101C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable metal ion binding activity and metallopeptidase activity. Involved in ribosomal large subunit export from nucleus. Located in cytoplasm; nucleolus; and nucleoplasm. Part of preribosome, large subunit precursor. Orthologous to human PA2G4 (proliferation-associated 2G4). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ARX1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (655686..657467, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene 14-3-3 family protein BMH2 Neighboring gene Tvp15p Neighboring gene uncharacterized protein Neighboring gene Ste5p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuclear recycling of the pre-60S ribosomal subunit-associated factor Arx1 depends on Rei1 in Saccharomyces cerevisiae. Hung NJ, et al. Mol Cell Biol, 2006 May. PMID 16648468, Free PMC Article
    2. The cytosolic J-protein, Jjj1, and Rei1 function in the removal of the pre-60 S subunit factor Arx1. Meyer AE, et al. J Biol Chem, 2010 Jan 8. PMID 19901025, Free PMC Article
    3. A conserved domain important for association of eukaryotic J-protein co-chaperones Jjj1 and Zuo1 with the ribosome. Kaschner LA, et al. Biochim Biophys Acta, 2015 May. PMID 25639645, Free PMC Article
    4. A dynamic model of proteome changes reveals new roles for transcript alteration in yeast. Lee MV, et al. Mol Syst Biol, 2011 Jul 19. PMID 21772262, Free PMC Article
    5. The Hsp40 chaperone Jjj1 is required for the nucleo-cytoplasmic recycling of preribosomal factors in Saccharomyces cerevisiae. Demoinet E, et al. RNA, 2007 Sep. PMID 17652132, Free PMC Article

    See all (164) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. suggest that, in addition to the role of Arx1 during pre-60S nuclear export, the binding of Arx1 conformationally locks the pre-60S subunit and inhibits the premature association of nascent chain-processing factors to the polypeptide tunnel exit
      Title: Cryo-EM structures of Arx1 and maturation factors Rei1 and Jjj1 bound to the 60S ribosomal subunit.
    2. binding of Arx1 at the exit tunnel may position this export factor to prevent premature recruitment of ribosome-associated factors active during translation
      Title: Structure of the pre-60S ribosomal subunit with nuclear export factor Arx1 bound at the exit tunnel.
    3. both Rei1 and Jjj1 are required for dissociation of Arx1 from the pre-60 S subunit, and the region of Jjj1 that mediates interaction with Rei1 is required in vivo for 60 S subunit biogenesis
      Title: The cytosolic J-protein, Jjj1, and Rei1 function in the removal of the pre-60 S subunit factor Arx1.
    4. Arx1 acts as an export receptor for the 60S subunit.
      Title: Arx1 is a nuclear export receptor for the 60S ribosomal subunit in yeast.
    5. Nuclear recycling of the pre-60S ribosomal subunit-associated factor Arx1 depends on Rei1.
      Title: Nuclear recycling of the pre-60S ribosomal subunit-associated factor Arx1 depends on Rei1 in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit export from nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ribosomal large subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative hydrolase
    NP_010386.1
    • Nuclear export factor for the ribosomal pre-60S subunit; shuttling factor which directly binds FG rich nucleoporins and facilities translocation through the nuclear pore complex; interacts directly with Alb1p; responsible for Tif6p recycling defects in the absence of Rei1; associated with the ribosomal export complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      655686..657467 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180409.1 → NP_010386.1  TPA: putative hydrolase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010386.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS88, Q03862
      UniProtKB/TrEMBL
      A6ZY65, B3LGH3
      Conserved Domains (1) summary
      cl00279
      Location:25 → 285
      APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03862.1

    Gene LinkOut

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