U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    RFT1 glycolipid translocation protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852261, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    RFT1
    Official Full Name
    glycolipid translocation protein
    Primary source
    SGD:S000000116
    Locus tag
    YBL020W
    See related
    AllianceGenome:SGD:S000000116; FungiDB:YBL020W; VEuPathDB:YBL020W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables flippase activity. Involved in glycolipid translocation. Located in endoplasmic reticulum membrane. Used to study cancer and congenital disorder of glycosylation type I. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation In. Orthologous to human RFT1 (RFT1 homolog). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See RFT1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (182401..184125)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene ATP-dependent Lon protease PIM1 Neighboring gene Hap3p Neighboring gene DNA-(apurinic or apyrimidinic site) lyase APN2 Neighboring gene ribonuclease P

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Suppression of Rft1 expression does not impair the transbilayer movement of Man5GlcNAc2-P-P-dolichol in sealed microsomes from yeast. Rush JS, et al. J Biol Chem, 2009 Jul 24. PMID 19494107, Free PMC Article
    2. Suppression of the yeast mutation rft1-1 by human p53. Koerte A, et al. J Biol Chem, 1995 Sep 22. PMID 7673248
    3. Distinct flippases translocate glycerophospholipids and oligosaccharide diphosphate dolichols across the endoplasmic reticulum. Sanyal S, et al. Biochemistry, 2008 Jul 29. PMID 18597486, Free PMC Article
    4. Does Rft1 flip an N-glycan lipid precursor? Frank CG, et al. Nature, 2008 Jul 31. PMID 18668045
    5. Rft1 catalyzes lipid-linked oligosaccharide translocation across the ER membrane. Chen S, et al. Nat Commun, 2024 Jun 17. PMID 38886340, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables flippase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dolichol-linked oligosaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolipid translocation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycolipid translocation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in glycolipid translocation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    glycolipid translocation protein
    NP_009533.1
    • Membrane protein required for translocation of Man5GlcNac2-PP-Dol; required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein; essential gene

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      182401..184125
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178260.1 → NP_009533.1  TPA: glycolipid translocation protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009533.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPY0, P38206, Q05814
      UniProtKB/TrEMBL
      A6ZKS8, B3LNF7, B5VDW0, C7GX90, C8Z3X6, G2W8Y9, N1P7F2
      Conserved Domains (1) summary
      pfam04506
      Location:18 → 563
      Rft-1; Rft protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38206.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools