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    ppa2 serine/threonine protein phosphatase PP2A catalytic subunit Ppa2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540072, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ppa2
    Official Full Name
    serine/threonine protein phosphatase PP2A catalytic subunit Ppa2
    Primary source
    PomBase:SPBC16H5.07c
    Locus tag
    SPOM_SPBC16H5.07C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See ppa2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (2286952..2290445)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ATP-binding cassette sub-family F protein Neighboring gene alpha-1,2-mannosyltransferase Omh2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Rieske iron-sulfur protein, ubiquinol-cytochrome-c reductase complex subunit 5, Rip1 Neighboring gene ncRNA Neighboring gene protein gem8 Neighboring gene cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fission yeast homologue of Tip41-like proteins regulates type 2A phosphatases and responses to nitrogen sources. Fenyvuesvolgyi C, et al. Biochim Biophys Acta, 2005 Dec 15. PMID 16297994
    2. Negative regulation of mitosis by the fission yeast protein phosphatase ppa2. Kinoshita N, et al. Genes Dev, 1993 Jun. PMID 8389306
    3. The regulatory subunits of fission yeast protein phosphatase 2A (PP2A) affect cell morphogenesis, cell wall synthesis and cytokinesis. Kinoshita K, et al. Genes Cells, 1996 Jan. PMID 9078365
    4. Distinct, essential roles of type 1 and 2A protein phosphatases in the control of the fission yeast cell division cycle. Kinoshita N, et al. Cell, 1990 Oct 19. PMID 2170029
    5. Fission yeast homologues of the B' subunit of protein phosphatase 2A: multiple roles in mitotic cell division and functional interaction with calcineurin. Tanabe O, et al. Genes Cells, 2001 May. PMID 11380623

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reduction of PP2A activity affects Cdc7p anaphase asymmetry.
      Title: Characterization of ypa1 and ypa2, the Schizosaccharomyces pombe orthologs of the peptidyl proyl isomerases that activate PP2A, reveals a role for Ypa2p in the regulation of cytokinesis.
    2. PP2A-Pab1 may be involved in coordinating polar growth and cytokinesis.
      Title: Antagonistic roles of PP2A-Pab1 and Etd1 in the control of cytokinesis in fission yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables phosphoprotein phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in meiotic centromeric cohesion protection in anaphase I EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in meiotic centromeric cohesion protection in anaphase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of induction of conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of septation initiation signaling EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 
    part_of protein phosphatase type 2A complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine protein phosphatase PP2A catalytic subunit Ppa2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2286952..2290445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021848.3 → NP_595940.1  serine/threonine protein phosphatase PP2A catalytic subunit Ppa2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595940.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P23636
      Conserved Domains (2) summary
      PTZ00239
      Location:22 → 322
      PTZ00239; serine/threonine protein phosphatase 2A; Provisional
      cd07415
      Location:22 → 306
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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