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    pom1 DYRK family cell polarity protein kinase Pom1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541889, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pom1
    Official Full Name
    DYRK family cell polarity protein kinase Pom1
    Primary source
    PomBase:SPAC2F7.03c
    Locus tag
    SPOM_SPAC2F7.03C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See pom1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (534120..537873, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene saccharopine dehydrogenase Lys3 Neighboring gene ncRNA Neighboring gene NLI-interacting factor-like phosphatase Psr1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mediator complex subunit Med1 Neighboring gene translation initiation factor Tif5 Neighboring gene DNA polymerase X family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stable Pom1 clusters form a glucose-modulated concentration gradient that regulates mitotic entry. Allard CAH, et al. Elife, 2019 May 3. PMID 31050341, Free PMC Article
    2. Multi-phosphorylation reaction and clustering tune Pom1 gradient mid-cell levels according to cell size. Gerganova V, et al. Elife, 2019 May 3. PMID 31050340, Free PMC Article
    3. Pom1 gradient buffering through intermolecular auto-phosphorylation. Hersch M, et al. Mol Syst Biol, 2015 Jul 6. PMID 26150232, Free PMC Article
    4. Noise reduction in the intracellular pom1p gradient by a dynamic clustering mechanism. Saunders TE, et al. Dev Cell, 2012 Mar 13. PMID 22342545, Free PMC Article
    5. The cell-end factor pom1p inhibits mid1p in specification of the cell division plane in fission yeast. Padte NN, et al. Curr Biol, 2006 Dec 19. PMID 17140794

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DYRK kinase Pom1 drives F-BAR protein Cdc15 from the membrane to promote medial division.
      Title: DYRK kinase Pom1 drives F-BAR protein Cdc15 from the membrane to promote medial division.
    2. This work reveals how Pom1-Cdr2-Wee1 operates in multiprotein clusters at the cortex to promote mitotic entry at a cell size that can be modified by nutrient availability.
      Title: Stable Pom1 clusters form a glucose-modulated concentration gradient that regulates mitotic entry.
    3. An allelic series blocking auto-phosphorylation shows that multi-phosphorylation shapes and the Pom1 gradient to control mid-cell levels, which represent the critical Cdr2-regulating pool.
      Title: Multi-phosphorylation reaction and clustering tune Pom1 gradient mid-cell levels according to cell size.
    4. Ssp1 promotes cell polarity by phosphorylating the activation loop of the MARK/PAR-1 family kinase Kin1. Additional Kin1 substrates for cell polarity and cytokinesis were also phosphorylated by the DYRK family member Pom1.
      Title: Mechanisms Connecting the Conserved Protein Kinases Ssp1, Kin1, and Pom1 in Fission Yeast Cell Polarity and Division.
    5. distinct levels in Pom1 gradients delineate a medial Cdr2 domain, for cell division placement, and control its activity, for mitotic commitment. [Pom1; Cdr2]
      Title: Distinct levels in Pom1 gradients limit Cdr2 activity and localization to time and position division.
    6. PKA signalling tunes CLASP's activity to promote Pom1 cell side localization and buffer cell size upon glucose starvation.
      Title: PKA antagonizes CLASP-dependent microtubule stabilization to re-localize Pom1 and buffer cell size upon glucose limitation.
    7. Results demonstrate that Pom1 auto-phosphorylates intermolecularly, both in vitro and in vivo, which confers robustness to the gradient.
      Title: Pom1 gradient buffering through intermolecular auto-phosphorylation.
    8. Cdr2 was the only cell cycle target of Pom1 kinase activity that was identified in cells.
      Title: Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
    9. The dual regulation exerted by Pom1 on Cdr2 prevents Cdr2 assembly into stable nodes in the cell tip region where Pom1 concentration is high.
      Title: Pom1 regulates the assembly of Cdr2-Mid1 cortical nodes for robust spatial control of cytokinesis.
    10. Pom1 phosophorylated the C-terminal domain of Cdr2, and this modification reduced Cdr2-T166 phosphorylation by Ssp1
      Title: Dueling kinases regulate cell size at division through the SAD kinase Cdr2.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables phosphatidylinositol phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of bipolar cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of actin cytoskeleton polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of bipolar cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic G2 cell size control checkpoint signaling EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in mitotic G2 cell size control checkpoint signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic G2 cell size control checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell integrity MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein localization to cell tip IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic cytokinesis, division site positioning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of establishment or maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell cortex of cell tip EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in cell cortex of cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell division site EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell tip EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic side of plasma membrane, cell tip EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lateral cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring, intermediate layer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in site of polarized growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DYRK family cell polarity protein kinase Pom1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      534120..537873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018374.3 → NP_592974.1  DYRK family cell polarity protein kinase Pom1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_592974.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q09690
      Conserved Domains (2) summary
      smart00220
      Location:699 → 995
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14210
      Location:685 → 995
      PKc_DYRK; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase
    Nucleotide Protein
    Heading Accession and Version

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