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    pik3 phosphatidylinositol 3-kinase Pik3 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543444, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pik3
    Official Full Name
    phosphatidylinositol 3-kinase Pik3
    Primary source
    PomBase:SPAC458.05
    Locus tag
    SPOM_SPAC458.05
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    vps34
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    Genomic context

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    See pik3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (4740117..4742814)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene meiotic dynein intermediate light chain Dli1/Dil1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene WD repeat-containing protein Atg1803 Neighboring gene transcription factor TFIIE subunit Tfa1 Neighboring gene MAP kinase-interacting protein Sin1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of phosphatidylinositol 3-phosphate in formation of forespore membrane in Schizosaccharomyces pombe. Onishi M, et al. Yeast, 2003 Feb. PMID 12557273
    2. Schizosaccharomyces pombe Vps34p, a phosphatidylinositol-specific PI 3-kinase essential for normal cell growth and vacuole morphology. Takegawa K, et al. J Cell Sci, 1995 Dec. PMID 8719881
    3. Phosphatidylinositol-3 kinase in fission yeast: a possible role in stress responses. Kimura K, et al. Biosci Biotechnol Biochem, 1995 Apr. PMID 7772832
    4. Schizosaccharomyces pombe Sst4p, a conserved Vps27/Hrs homolog, functions downstream of phosphatidylinositol 3-kinase Pik3p to mediate proper spore formation. Onishi M, et al. Eukaryot Cell, 2007 Dec. PMID 17951524, Free PMC Article
    5. Sorting nexin homologues are targets of phosphatidylinositol 3-phosphate in sporulation of Schizosaccharomyces pombe. Koga T, et al. Genes Cells, 2004 Jun. PMID 15189449

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sst4p is a downstream factor of PtdIns 3-kinase and functions in forespore membrane formation
      Title: Schizosaccharomyces pombe Sst4p, a conserved Vps27/Hrs homolog, functions downstream of phosphatidylinositol 3-kinase Pik3p to mediate proper spore formation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol-3-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-phosphatidylinositol-3-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ascospore-type prospore assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ascospore-type prospore membrane formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy of peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol-3-phosphate biosynthetic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class III, type I EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex, class III, type I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class III, type I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex, class III, type II EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex, class III, type II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class III, type II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol 3-kinase Pik3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4740117..4742814
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020127.3 → NP_594699.1  phosphatidylinositol 3-kinase Pik3 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594699.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P50520, Q9P3W3, Q9URD2
      Conserved Domains (4) summary
      COG5032
      Location:1 → 801
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd00870
      Location:257 → 422
      PI3Ka_III; Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III ...
      cd00896
      Location:450 → 797
      PI3Kc_III; Catalytic domain of Class III Phosphoinositide 3-kinase
      cl14603
      Location:30 → 181
      C2; C2 domain
    Nucleotide Protein
    Heading Accession and Version

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