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    cdc16 two-component GAP Cdc16 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542162, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cdc16
    Official Full Name
    two-component GAP Cdc16
    Primary source
    PomBase:SPAC6F6.08c
    Locus tag
    SPOM_SPAC6F6.08C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    bub2
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    Genomic context

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    See cdc16 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003424.3 (2746667..2748156, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene cell polarity factor Rax2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 40S ribosomal protein uS15 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NuA4 histone acetyltransferase complex subunit Eaf6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Uncontrolled septation in a cell division cycle mutant of the fission yeast Schizosaccharomyces pombe. Minet M, et al. J Bacteriol, 1979 Jan. PMID 762020, Free PMC Article
    2. The fission yeast dma1 gene is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is compromised. Murone M, et al. EMBO J, 1996 Dec 2. PMID 8978687, Free PMC Article
    3. Dynamics of SIN asymmetry establishment. Bajpai A, et al. PLoS Comput Biol, 2013. PMID 23874188, Free PMC Article
    4. Regions of Byr4, a regulator of septation in fission yeast, that bind Spg1 or Cdc16 and form a two-component GTPase-activating protein with Cdc16. Furge KA, et al. J Biol Chem, 1999 Apr 16. PMID 10196225
    5. The role of Plo1 kinase in mitotic commitment and septation in Schizosaccharomyces pombe. Tanaka K, et al. EMBO J, 2001 Mar 15. PMID 11250892, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tea4-PP1 landmark promotes local Cdc42 activation and growth both through Cdc42 GEF recruitment and by creating a local trough in a Cdc42 GAP.
      Title: The Tea4-PP1 landmark promotes local growth by dual Cdc42 GEF recruitment and GAP exclusion.
    2. We propose a mechanism that limits the amount of the Byr4p-Cdc16p GAP to the amount required to inhibit Spg1p signalling.
      Title: Homoeostasis between the GTPase Spg1p and its GAP in the regulation of cytokinesis in S. pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    contributes_to GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of division septum assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of mitotic cytokinesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of septation initiation signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of septation initiation signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Bfa1-Bub2 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in mitotic spindle pole body HDA PubMed 
    is_active_in mitotic spindle pole body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in old mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    two-component GAP Cdc16

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2746667..2748156 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019331.3 → NP_593901.1  two-component GAP Cdc16 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593901.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P36618
      Conserved Domains (2) summary
      smart00164
      Location:38 → 244
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG5210
      Location:1 → 299
      COG5210; GTPase-activating protein [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version

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