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    leo1 RNA polymerase II-associated Paf1 complex protein Leo1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539726, updated on 18-Sep-2024

    Summary

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    Official Symbol
    leo1
    Official Full Name
    RNA polymerase II-associated Paf1 complex protein Leo1
    Primary source
    PomBase:SPBC13E7.08c
    Locus tag
    SPOM_SPBC13E7.08C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See leo1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (3052520..3055140, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene pig-M family mannosyltransferase Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene microtubule-anchoring factor Msd1 Neighboring gene verprolin Neighboring gene transcription factor TFIIIB subunit Brf1 Neighboring gene rhomboid protease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Leo1 is essential for the dynamic regulation of heterochromatin and gene expression during cellular quiescence. Oya E, et al. Epigenetics Chromatin, 2019 Jul 17. PMID 31315658, Free PMC Article
    2. The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast. Seo HD, et al. Curr Genet, 2018 Jun. PMID 29214404
    3. Spt5 Phosphorylation and the Rtf1 Plus3 Domain Promote Rtf1 Function through Distinct Mechanisms. Chen JJ, et al. Mol Cell Biol, 2020 Jul 14. PMID 32366382, Free PMC Article
    4. The Paf1 complex factors Leo1 and Paf1 promote local histone turnover to modulate chromatin states in fission yeast. Sadeghi L, et al. EMBO Rep, 2015 Dec. PMID 26518661, Free PMC Article
    5. TOR complex 2 contributes to regulation of gene expression via inhibiting Gcn5 recruitment to subtelomeric and DNA replication stress genes. Cohen A, et al. PLoS Genet, 2022 Feb. PMID 35157728, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II C-terminal domain phosphoserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heterochromatin boundary formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin organization EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in positive regulation of transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cdc73/Paf1 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA polymerase II-associated Paf1 complex protein Leo1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3052520..3055140 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022183.3 → NP_596263.1  RNA polymerase II-associated Paf1 complex protein Leo1 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9P6R2
      Conserved Domains (1) summary
      pfam04004
      Location:89 → 248
      Leo1; Leo1-like protein
    Nucleotide Protein
    Heading Accession and Version

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