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    GSF2 Gsf2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854957, updated on 29-Jun-2024

    Summary

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    Gene symbol
    GSF2
    Gene description
    Gsf2p
    Primary source
    FungiDB:YML048W
    Locus tag
    YML048W
    See related
    SGD:S000004511; AllianceGenome:SGD:S000004511; VEuPathDB:YML048W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ECM6
    Summary
    Enables unfolded protein binding activity. Involved in protein folding and protein localization to cell surface. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GSF2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (178426..179637)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Aim32p Neighboring gene U2 snRNP complex subunit RSE1 Neighboring gene pheromone-regulated K(+) transporter PRM6 Neighboring gene Prp39p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GSF2 deletion increases lactic acid production by alleviating glucose repression in Saccharomyces cerevisiae. Baek SH, et al. Sci Rep, 2016 Oct 6. PMID 27708428, Free PMC Article
    2. Mutations in GSF1 and GSF2 alter glucose signaling in Saccharomyces cerevisiae. Sherwood PW, et al. Genetics, 1997 Oct. PMID 9335593, Free PMC Article
    3. Efficient export of the glucose transporter Hxt1p from the endoplasmic reticulum requires Gsf2p. Sherwood PW, et al. Proc Natl Acad Sci U S A, 1999 Jun 22. PMID 10377429, Free PMC Article
    4. Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER. Kota J, et al. J Cell Biol, 2005 Jan 3. PMID 15623581, Free PMC Article
    5. A systematic approach to pair secretory cargo receptors with their cargo suggests a mechanism for cargo selection by Erv14. Herzig Y, et al. PLoS Biol, 2012. PMID 22629230, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables unfolded protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein folding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to cell surface IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein localization to cell surface IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane HDA PubMed 

    General protein information

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    Preferred Names
    Gsf2p
    NP_013664.1
    • Endoplasmic reticulum (ER) localized integral membrane protein; may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      178426..179637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182405.1 → NP_013664.1  TPA: Gsf2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013664.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZC7, Q04697
      UniProtKB/TrEMBL
      A0A8H4F9G2, A6ZM19, B3LLK9, B5VP82, C7GS64, N1NZ11
      Conserved Domains (1) summary
      pfam11055
      Location:1 → 384
      Gsf2; Glucose signalling factor 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04697.1

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