U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    COX8 cytochrome c oxidase subunit VIII [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851111, updated on 29-Jun-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    COX8
    Gene description
    cytochrome c oxidase subunit VIII
    Primary source
    FungiDB:YLR395C
    Locus tag
    YLR395C
    See related
    SGD:S000004387; AllianceGenome:SGD:S000004387; VEuPathDB:YLR395C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to cytochrome-c oxidase activity. Involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. Part of mitochondrial respiratory chain complex IV. Orthologous to human COX7C (cytochrome c oxidase subunit 7C). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See COX8 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (909729..909965, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Atp10p Neighboring gene SUMO ligase CST9 Neighboring gene tethering complex ATP-binding subunit VPS33 Neighboring gene AAA family ATPase AFG2

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The nuclear-coded subunits of yeast cytochrome c oxidase. II. The amino acid sequence of subunit VIII and a model for its disposition in the inner mitochondrial membrane. Power SD, et al. J Biol Chem, 1984 May 25. PMID 6327685
    2. COX8, the structural gene for yeast cytochrome c oxidase subunit VIII. DNA sequence and gene disruption indicate that subunit VIII is required for maximal levels of cellular respiration and is derived from a precursor which is extended at both its NH2 and COOH termini. Patterson TE, et al. J Biol Chem, 1986 Dec 25. PMID 3023386
    3. The nuclear-coded subunits of yeast cytochrome c oxidase. I. Fractionation of the holoenzyme into chemically pure polypeptides and the identification of two new subunits using solvent extraction and reversed phase high performance liquid chromatography. Power SD, et al. J Biol Chem, 1984 May 25. PMID 6327684
    4. The nuclear-coded subunits of yeast cytochrome c oxidase. The amino acid sequences of subunits VII and VIIa, structural similarities between the three smallest polypeptides of the holoenzyme, and implications for biogenesis. Power SD, et al. J Biol Chem, 1986 Jul 15. PMID 3013877
    5. Effects of oxygen concentration on the expression of cytochrome c and cytochrome c oxidase genes in yeast. Burke PV, et al. J Biol Chem, 1997 Jun 6. PMID 9169434

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to cytochrome-c oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oxidative phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex IV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cytochrome c oxidase subunit VIII
    NP_013499.1
    • Subunit VIII of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      909729..909965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182283.1 → NP_013499.1  TPA: cytochrome c oxidase subunit VIII [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013499.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ30, P04039
      UniProtKB/TrEMBL
      A0A6A5PRD8, A7A1S0, B3RHR0, C7GXJ9, C8ZE04, G2WJL0, N1P060
      Conserved Domains (1) summary
      pfam02935
      Location:26 → 74
      COX7C; Cytochrome c oxidase subunit VIIc
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04039.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools