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    RSC2 Rsc2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851071, updated on 29-Jun-2024

    Summary

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    Gene symbol
    RSC2
    Gene description
    Rsc2p
    Primary source
    FungiDB:YLR357W
    Locus tag
    YLR357W
    See related
    SGD:S000004349; AllianceGenome:SGD:S000004349; VEuPathDB:YLR357W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables chromatin binding activity. Involved in DNA repair; chromosome organization; and transcription elongation from RNA polymerase II promoter. Part of RSC-type complex. Human ortholog(s) of this gene implicated in extrahepatic bile duct adenocarcinoma; lung non-small cell carcinoma; lung small cell carcinoma; and renal cell carcinoma. Orthologous to human PBRM1 (polybromo 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RSC2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (841331..844000)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ketol-acid reductoisomerase Neighboring gene Atg33p Neighboring gene uncharacterized protein Neighboring gene adenylosuccinase ADE13 Neighboring gene Vps38p Neighboring gene phosphoprotein phosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A role for chromatin remodellers in replication of damaged DNA. Niimi A, et al. Nucleic Acids Res, 2012 Aug. PMID 22638582, Free PMC Article
    2. Concurrent fast and slow cycling of a transcriptional activator at an endogenous promoter. Karpova TS, et al. Science, 2008 Jan 25. PMID 18218898
    3. Functional differences between RSC1 and RSC2, components of a for growth essential chromatin-remodeling complex of Saccharomyces cerevisiae, during the sporulation process. Yukawa M, et al. FEMS Yeast Res, 2002 May. PMID 12702296
    4. RSC2, encoding a component of the RSC nucleosome remodeling complex, is essential for 2 microm plasmid maintenance in Saccharomyces cerevisiae. Wong MC, et al. Mol Cell Biol, 2002 Jun. PMID 12024034, Free PMC Article
    5. Genome-wide location and regulated recruitment of the RSC nucleosome-remodeling complex. Ng HH, et al. Genes Dev, 2002 Apr 1. PMID 11937489, Free PMC Article

    See all (150) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Specialization of the chromatin remodeler RSC to mobilize partially-unwrapped nucleosomes.
      Title: Specialization of the chromatin remodeler RSC to mobilize partially-unwrapped nucleosomes.
    2. Results show that H4 acetylation by the NuA4 complex and RSC2 are both required for gap-induced sister chromatid recombination.
      Title: NuA4 initiates dynamic histone H4 acetylation to promote high-fidelity sister chromatid recombination at postreplication gaps.
    3. This study uncovered a direct interaction between the Rsc2 BAH domain and histone H3 and led to the identification of an interaction interface that is conserved in a subset of Rsc-like BAH domains.
      Title: The BAH domain of Rsc2 is a histone H3 binding domain.
    4. Data show that RSC1 and RSC2 are haploinsufficient for spore formation in a smk1 hypomorph.
      Title: RSC1 and RSC2 are required for expression of mid-late sporulation-specific genes in Saccharomyces cerevisiae.
    5. RSC2 may function through the tRNA element to restric the spread of silencing
      Title: Multiple bromodomain genes are involved in restricting the spread of heterochromatic silencing at the Saccharomyces cerevisiae HMR-tRNA boundary.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in UV-damage excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via nonhomologous end joining IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in nucleosome disassembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RSC-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RSC-type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RSC-type complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rsc2p
    NP_013461.1
    • Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance; RSC2 has a paralog, RSC1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      841331..844000
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182246.1 → NP_013461.1  TPA: Rsc2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013461.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYZ5, Q06488
      UniProtKB/TrEMBL
      A0A6A5PTQ6, A7A1N5, C7GRY2, C8ZDW4, G2WJH5, N1P028
      Conserved Domains (2) summary
      cd05521
      Location:17 → 121
      Bromo_Rsc1_2_I; Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two ...
      COG5076
      Location:123 → 503
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06488.1

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